Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study.

Background: In this study, we aimed to explore the association between baseline and early changes in the neutrophil-to-lymphocyte ratio (NLR) and the 30-day mortality rate in patients having anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis with interstitial lung disease (DM-ILD).

Methods: Overall, 263 patients with anti-MDA5 DM-ILD from four centers in China were analyzed. Multivariate logistic regression analysis was used to evaluate the impact of baseline NLR on the 30-day mortality rate in patients with anti-MDA5-positive DM-ILD.

Bose-Einstein condensation of a two-magnon bound state in a spin-1 triangular lattice.

In ordered magnets, the elementary excitations are spin waves (magnons), which obey Bose-Einstein statistics. Similarly to Cooper pairs in superconductors, magnons can be paired into bound states under attractive interactions. The Zeeman coupling to a magnetic field is able to tune the particle density through a quantum critical point, beyond which a 'hidden order' is predicted to exist.

Photochemistry of dissolved organic matter derived from compost.

The extensive application of compost to enhance soil quality highlights the crucial role of dissolved organic matter (DOM) derived from compost in both terrestrial and aquatic ecosystems, influencing carbon cycling and the fate of contaminants. However, the photochemical behavior of compost-derived DOM (DOM) remains poorly understood. In this study, we investigated the photochemical transformation and photoactivity of DOM derived from typical composts produced from cow manure (CDOM) and pig manure (PDOM).

Mechanochemical Release of 9,10-Diphenylanthracene via Flex-Activation of Its 1,4-Diels-Alder Adduct.

Flex-activated mechanophores capable of releasing small molecules utilize bond bending to facilitate their mechanochemical activation without compromising the overall macromolecular architecture, which have great potential in various applications. However, the development of such mechanophores remains underexplored. Here we report a novel flex-activated mechanophore based on the 1,4-Diels-Alder (DA) adduct of 9,10-diphenylanthracene (DPA) with acetylenedicarboxylate (ADC).

Arachnoid Cyst Associated With Traumatic Chronic Subdural Hemorrhage in Children.

Introduction: It was reported that most arachnoid cyst (AC)-associated chronic subdural hematoma (CSDH) was spontaneous. However, AC with CSDH caused by trauma was extremely scarcely reported. In this paper, the authors reported a successful surgical treatment of a case of AC associated with CSDH after trauma.

Effects of selenate on greenhouse gas release and microbial community variations during swine manure composting.

Co-composting of livestock manure and selenate is an effective means to produce selenium-rich organic fertilizer. However the effect of selenate on greenhouse gas emission during composting is still unknown. To probe the influences of selenate on greenhouse gas and microbial community changes during swine manure composting.

Volatile Flavor Analysis in Yak Meat: Effects of Different Breeds, Feeding Methods, and Parts Using GC-IMS and Multivariate Analyses.

This study investigates the effects of breeds, feeding methods, and parts on the volatile flavor of yak meat. Gas chromatography-ion mobility spectrometry (GC-IMS) and multivariate analysis were used to analyze the volatile organic components (VOCs) in yak meat from various sources. A total of 71 volatile compounds were identified, 53 of which were annotated based on the GC-IMS database.

Polymer Mechanochemistry in Confined Spaces.

With the development of mechanophores, polymer mechanochemistry has emerged as a powerful tool for creating force-responsive materials with a variety of desired functions, ranging from color change to molecular release. However, it remains challenging to improve the efficiency of mechanochemical activation, especially for mechanophores embedded within polymer networks, which has profound implications for translating mechanochemical responses into materials-centered applications. The physical and chemical conditions under spatial confinement differ significantly from those in the surrounding bulk environment, offering opportunities to facilitate mechanochemical activation.

Elevated HSPB1 Expression Is Associated with a Poor Prognosis in Glioblastoma Multiforme Patients.

Background:  Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer. This study investigated the clinical predictive value of heat shock protein β1 (HSPB1) in patients with GBM.

Methods:  A correlation was established between HSPB1 expression and GBM progression using data from The Cancer Genome Atlas (TCGA) dataset, Chinese Glioma Genome Atlas dataset, Gene Expression Omnibus dataset, and Human Protein Atlas database.

CSF3 aggravates acute exacerbation of pulmonary fibrosis by disrupting alveolar epithelial barrier integrity.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive respiratory disorder characterized by poor prognosis, often presenting with acute exacerbation. The primary cause of death associated with IPF is acute exacerbation of IPF (AE-IPF). However, the pathophysiology of acute exacerbation has not been clearly elucidated yet.

GC-IMS and multivariate analyses of volatile organic components in different Chinese breeds of chickens.

This study examined the difference in volatile flavor characteristics among four different local breeds of chicken by headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) combined with multivariate analysis. In total, 65 volatile organic compounds (VOCs) were identified (17 aldehydes, 12 alcohols, 7 ketones, 5 esters, 2 acids, and 22 unidentified, i.e.

Parameter-Free and Electron Counting Satisfied Material Representation for Machine Learning Potential Energy and Force Fields.

We proposed a parameter-free volume element representation that satisfies the electron counting model and obtains accurate machine learning potential energy and direct force fitting of randomly perturbed hexagonal BN. Our method preserves permutational, translational, and rotational invariance and can be extended to three-dimensional systems, verified by a system of bulk Si. As a result, we obtained 0.

Depleting ANTXR1 suppresses glioma growth via deactivating PI3K/AKT pathway.

Gliomas are commonly known as primary brain tumors and associated with frequent recurrence and an unsatisfactory prognosis despite extensive research in the underlying molecular mechanisms. We aimed to examine the role of ANTXR1 in glioma tumorigenesis and explore its downstream regulatory mechanism. ANTXR1 expression in clinical specimens and its relationship with some pathological characteristics were detected using immunohistochemical staining.

Application of an innovative pancreaticojejunostomy technique with a modified set of perioperative management in pancreatoduodenectomy: a retrospective cohort study.

How to reduce grade C postoperative pancreatic fistula (POPF) incidence after pancreaticoduodenectomy (PD) is the pursuit of pancreatic surgeons. This study introduced an innovative pancreaticojejunostomy (PJ) technique with a complete set of perioperative management. All 144 patients in this single-center retrospective cohort study underwent the same PJ technique and perioperative management.

Exploring the link between microbial community structure and flavour compounds of traditional fermented yak milk in Gannan region.

Traditional fermented yak milk has immense cultural and nutritional significance for Tibetan herders. In this study, we investigated the microbial community structure and flavour compounds in traditional fermented yak milk from three distinct regions of Gannan to explore the relationship between microbial composition and flavour compounds. The findings revealed significant variations in flavour compounds and the bacterial microbiota among the samples from the three regions.

Does environmental protection tax improve green total factor productivity? Experimental evidence from China.

Enhancing green total factor productivity (GTFP) is essential for achieving the objective of green development, and the effect of environmental protection tax (EPT), a crucial instrument for addressing environmental challenges, on green TFP is crucial. Based on provincial panel data from 2004 to 2020 in China, this study uses inter-provincial differences in environmental protection tax rates as a quasi-natural experiment and utilizes a synthetic control method to assess the impact of the "changing sewage charge to tax" on regional GTFP. The empirical results suggest that EPT can help enhance GTFP, a finding that still holds after regional placebo tests, time placebo tests, and difference-in-differences robustness tests.

Yak milk and its health benefits: a comprehensive review.

Yak milk has various potential health benefits due to its high nutritional content and unique composition. It is an excellent source of protein, essential fatty acids, vitamins, and minerals, which can promote overall health and wellbeing. Yak milk may have potential therapeutic benefits for hypertension, as it contains peptides that have been shown to have antihypertensive effects.

Sintilimab-induced Alopecia Universalis in a Patient With the Anti-tumor Effect of Complete Remission After Hepatectomy.

Immune checkpoint blockades have been widely used to treat various malignancies. Programmed cell death protein 1 (PD-1) inhibitor-induced alopecia areata, one of the immune-related adverse events, is rarely reported. We present a case of alopecia universalis during the treatment of Sintilimab, a monoclonal anti-PD-1 antibody, in a patient with hepatocellular carcinoma.

Ginsenoside Rg1 attenuation of neurogenesis disorder and neuronal apoptosis in the rat hippocampus after spinal cord injury may involve brain-derived neurotrophic factor/extracellular signal-regulated kinase signaling.

Objective: We previously demonstrated that spinal cord injury (SCI) induced hippocampus injury and depression in rodents. Ginsenoside Rg1 effectively prevents neurodegenerative disorders. Here, we investigated the effects of ginsenoside Rg1 on the hippocampus after SCI.

Two-dimensional quantum universality in the spin-1/2 triangular-lattice quantum antiferromagnet NaBaCo(PO).

An interplay of geometrical frustration and strong quantum fluctuations in a spin-1/2 triangular-lattice antiferromagnet (TAF) can lead to exotic quantum states. Here, we report the neutron-scattering, magnetization, specific heat, and magnetocaloric studies of the recently discovered spin-1/2 TAF NaBaCo(PO), which can be described by a spin-1/2 easy axis XXZ model. The zero-field neutron diffraction experiment reveals an incommensurate antiferromagnetic ground state with a significantly reduced ordered moment of about 0.

The clinical feasibility of artificial intelligence-assisted compressed sensing single-shot fluid-attenuated inversion recovery (ACS-SS-FLAIR) for evaluation of uncooperative patients with brain diseases: comparison with the conventional T2-FLAIR with parallel imaging.

Background: Satisfactory magnetic resonance imaging (MRI) of those patients with involuntary head motion due to brain diseases is essential in avoiding missed diagnosis and guiding treatment.

Purpose: To investigate the clinical feasibility of artificial intelligence-assisted compressed sensing single-shot fluid-attenuated inversion recovery (ACS-SS-FLAIR) in evaluating patients with involuntary head motion due to brain diseases, compared with the conventional T2-FLAIR with parallel imaging (PI-FLAIR).

Material And Methods: A total of 33 uncooperative patients with brain disease were prospectively enrolled.

A Novel p-Type ZnCoO Thin Film Grown by Atomic Layer Deposition.

Reported herein is the atomic layer deposition (ALD) of novel ternary ZnCoO films possessing p-type semiconducting behavior. The preparation comprises of optimized ZnO and CoO deposition in sub-cycles using the commercially available precursors cyclopentadienylcobalt dicarbonyl (CpCo(CO)), diethylzinc (DEZ) and ozone (O). A systematic exploration of the film's microstructure, crystallinity, optical properties and electrical properties was conducted and revealed an association with Zn/Co stoichiometry.

The impact of clean energy development on economic growth in China: from the perspectives of environmental regulation.

Given the finite nature of fossil energy and rising environmental pressures, countries are increasing focus on clean energy. By employing provincial panel data from 2003 to 2019 in China, this study sheds light on the effect of clean energy development on economic growth and the role of environmental regulation in the relationship. The study utilized moderating and threshold effect models for empirical estimation.

Effect of lentinan on proliferation and apoptosis of human astrocytoma U251 cells.

Aim Of The Study: Aim of the study is To investigate the effect of lentinan on proliferation and apoptosis of human astrocytoma U251 cells. Lentinan was dissolved in DMEM complete medium to form different concentrations (0, 25, 50, 100, 200, 400, 500, 600 µg/ml). CCK8 was used to detect the effect of lentinan with different concentrations on proliferation of human astrocytoma U251 cells, and the expression of Ki-67 was detected by immunofluorescence.