CRISPR is easy: Exposure to Last Week Tonight enhances knowledge about gene editing.

Experts have called for public engagement with the governance of controversial scientific research and discoveries, including CRISPR, the technology that enables gene editing. Though engaging and informing citizens who are not interested in the issue is a challenge, recent studies suggest humor has potential to close interest and knowledge gaps. We tested this potential by exposing individuals (N = 303) to one of three videos (an edited clip from Last Week Tonight, an edited clip from 60 Minutes, or control) that contained broadly overlapping facts about gene editing in an online survey.

Behavioral Intentions to Donate Blood: The Interplay of Personality, Emotional Arousals, and the Moderating Effect of Altruistic versus Egoistic Messages on Young Adults.

Human blood is one of the most valuable and irreplaceable goods in modern medicine. Although its necessity increases daily, one of the most significant challenges we have to overcome is a scarcity of willing blood donors. Volunteer motives and attitudes have been studied for decades, but it is now considered vital to grasp the many aspects that will increase the effectiveness of attracting new blood donors.

Evaluation of Hemodynamic Properties After Chimney and Fenestrated Endovascular Aneurysm Repair.

Background: Fenestrated (FEVAR) and chimney (ChEVAR) endovascular aortic repair have been applied in anatomically suitable complex aortic aneurysms. However, local hemodynamic changes may occur after repair. This study aimed to compare FEVAR's and ChEVAR's hemodynamic properties, focusing on visceral arteries.

Examining expertise: Synthetic biology experts' perceptions of risk, benefit, and the public for research and applications regulation.

Scientific experts can play an important role in decision-making surrounding policy for technical and value-laden issues, often in contexts that directly affect lay publics. Yet little is known about what characterizes scientific experts who want lay public involvement in decision-making. In this study, we examine how synthetic biology experts' perceptions of risks, benefits, and ambivalence for synthetic biology relate to views of lay publics, deference to scientific authority, and regulations.

Relationship of Effective Circulating Volume with Sublingual Red Blood Cell Velocity and Microvessel Pressure Difference: A Clinical Investigation and Computational Fluid Dynamics Modeling.

The characteristics of physiologic hemodynamic coherence are not well-investigated. We examined the physiological relationship between circulating blood volume, sublingual microcirculatory perfusion, and tissue oxygenation in anesthetized individuals with steady-state physiology. We assessed the correlation of mean circulatory filling pressure analogue (Pmca) with sublingual microcirculatory perfusion and red blood cell (RBC) velocity using SDF+ imaging and a modified optical flow-based algorithm.

The science of YouTube: What factors influence user engagement with online science videos?

As the reach of science content in traditional media declines, many institutions and scientists are turning to YouTube as a powerful tool for communicating directly with non-expert publics. They do so with little empirical social science research guiding their efforts. This study explores how video characteristics and social endorsement cues provided by audience members might influence user engagement with online science videos.

Wall shear stress indicators influence the regular hemodynamic conditions in coronary main arterial diseases: cardiovascular abnormalities.

Computational hemodynamic (CH) characteristics play a central role in the onset and expansion of atherosclerotic plaques in the coronary main arteries. This study has explored the effects of hemodynamic properties especially coronary arterial wall tangential stresses on various healthy and diseased patient-based coronary artery models based on coronary computed tomography angiography (CCTA) imaging. The key components of the work are the CCTA image acquisition, accurate three-dimensional (3 D) model segmentation, reconstruction, appropriate grid generation, CH simulations, and analysis of the results by using open-source techniques.

Remodeling effects of carotid artery stenting versus endarterectomy with patch angioplasty in terms of morphology and hemodynamics.

Background: Carotid endarterectomy (CEA) remains the first-line treatment option of symptomatic and asymptomatic carotid stenosis, while stenting (CAS) is reserved for selected patients at high surgical risk. Here, we compare the vascular remodeling process in CEA- and CAS-treated patients with respect to morphological and hemodynamic features, because of their possible engagement in carotid atherosclerosis.

Methods: Twelve (12) patients were included, half with patched CEA and half with CAS.

Computational Fluid Dynamic Analysis Supports the Hemodynamic Stability of Hybrid Combinations With the AFX Bifurcate and Nitinol-Based Proximal Segments in Solutions of Failed Endovascular Aneurysm Repair.

Hybrid endograft combinations of two or more different types of covered stents are rarely reported to treat complex abdominal aortic aneurysm cases or primary and secondary endoleaks. Clinical and laboratory data regarding the clinical efficacy and mechanical stability of such combinations are lacking. Based on a recently published case report, we describe and comment on the hemodynamic profile of a representative simulated hybrid case of AFX and Nitinol-based proximal cuff and support the stability of this combination in non-angulated cases.

The state of GMOs on social media .

This study analyzes the relationship between state-level variables and Twitter discourse on genetically modified organisms (GMOs). Using geographically identified tweets related to GMOs, we examined how the sentiments expressed about GMOs related to education levels, news coverage, proportion of rural and urban counties, state-level political ideology, amount of GMO-related legislation introduced, and agricultural dependence of each U.S.

Modeling and Computational Comparison of the Displacement Forces Exerted between the AFX Unibody Aortic Stent Graft and its Hybrid Combination with a Nitinol-based Proximal Aortic Cuff.

Background: The bifurcated AFX (Endologix, Inc, Irvine, CA, USA) aortic stent-graft is the sole unibody endograft for the management of Abdominal Aortic Aneurysms (AAA). In order to improve the AFX central sealing and clinical efficacy in challenging cases, a replacement of the central chromium-cobaltium AFX extension with a Nitinol-based proximal aortic cuff has been suggested. Yet, comparative data regarding the hemodynamic performance of this design is missing.

What Do We (Not) Know About Global Views of Human Gene Editing? Insights and Blind Spots in the CRISPR Era.

As research on human applications of CRISPR advances, researchers, advisory bodies, and other stakeholder organizations continue calling for global public discourses and engagement to shape the development of human gene editing (HGE). Research that captures public views and tests ways for engaging across viewpoints is vital for facilitating these discourses. Unfortunately, such research lags behind advances in HGE research and applications.

Deference and decision-making in science and society: How deference to scientific authority goes beyond confidence in science and scientists to become authoritarianism.

theoretically captures the belief that scientists and not publics should make decisions on science in society. Few studies examine deference, however, and none test this central theoretical claim. The result is deference is often conflated with concepts such as trust in scientists and belief in the authority of science.

Endograft Specific Haemodynamics After Endovascular Aneurysm Repair: Flow Characteristics of Four Stent Graft Systems.

Objectives: The implication of haemodynamics in the occurrence of complications after endovascular aneurysm repair (EVAR) has been raised in the literature. Different aortic stent graft configurations may lead to different haemodynamic properties. The current study deals with the post-operative haemodynamic variability between four stent graft systems with different structure, material, and type of fixation.

In-stent graft helical flow intensity reduces the risk of migration after endovascular aortic repair.

During the last years endovascular aneurysm repair (EVAR) became the elective treatment for abdominal aortic aneurysms (AAAs) thanks to lower mortality and morbidity rates than open surgery. In face of these advantages, stent-graft performances are still clinically suboptimal. In particular, post-surgical complications derive from device migration as a consequence of the hemodynamic forces acting on the endograft.

National Academies of Sciences, Engineering, and Medicine report on genetically engineered crops influences public discourse.

In May 2016, the National Academies of Sciences, Engineering, and Medicine (NASEM) released the report "Genetically Engineered Crops: Experiences and Prospects," summarizing scientific consensus on genetically engineered crops and their implications. NASEM reports aim to give the public and policymakers information on socially relevant science issues. Their impact, however, is not well understood.

Engagement present and future: Graduate student and faculty perceptions of social media and the role of the public in science engagement.

Interest in public engagement with science activities has grown in recent decades, especially engagement through social media and among graduate students. Research on scientists' views of engagement, particularly two-way engagement and engagement through social media, is sparse, particularly research examining graduate students' views. We compare graduate students and faculty in biological and physical sciences at a land-grant, research-intensive university in their views on engagement.

Public views about editing genes in wildlife for conservation.

Developments in CRISPR-based gene-editing technologies have generated a growing number of proposals to edit genes in wildlife to meet conservation goals. As these proposals have attracted greater attention, controversies have emerged among scientists and stakeholder groups over potential consequences and ethical implications of gene editing. Responsible governance cannot occur without consulting broader publics, yet little effort has been made to systematically assess public understandings and beliefs in relation to this new area of applied genetic engineering.

Distinguishing scientific knowledge: The impact of different measures of knowledge on genetically modified food attitudes.

The impact of knowledge on public attitudes toward scientific issues remains unclear, due in part to ill-defined differences in how research designs conceptualize knowledge. Using genetically modified foods as a framework, we explore the impacts of perceived familiarity and factual knowledge, and the moderating roles of media attention and a food-specific attitudinal variable (food consciousness), in shaping these relationships. Based on the differential effects on "negative attitudes" toward genetically modified foods, we provide further evidence that the measures of knowledge are separate concepts and argue against a one-dimensional view of scientific knowledge.

Rethinking Social Amplification of Risk: Social Media and Zika in Three Languages.

Using the Zika outbreak as a context of inquiry, this study examines how assigning blame on social media relates to the social amplification of risk framework (SARF). Past research has discussed the relationship between the SARF and traditional mass media, but the role of social media platforms in amplification or attenuation of risk perceptions remains understudied. Moreover, the communication and perceptions of Zika-related risk are not limited to discussions in English.

Abdominal Aortic Aneurysm Endovascular Repair: Profiling Postimplantation Morphometry and Hemodynamics With Image-Based Computational Fluid Dynamics.

Endovascular aneurysm repair (EVAR) has disseminated rapidly as an alternative to open surgical repair for the treatment of abdominal aortic aneurysms (AAAs), because of its reduced invasiveness, low mortality, and morbidity rate. The effectiveness of the endovascular devices used in EVAR is always at question as postoperative adverse events can lead to re-intervention or to a possible fatal scenario for the circulatory system. Motivated by the assessment of the risks related to thrombus formation, here the impact of two different commercial endovascular grafts on local hemodynamics is explored through 20 image-based computational hemodynamic models of EVAR-treated patients (N = 10 per each endograft model).

Haemodynamic performance of AFX and Nellix endografts: a computational fluid dynamics study.

Objectives: The objective of this study is to analyse the flow conditions in the AFX and Nellix endografts (EGs) accounting for their postimplantation configuration in patients with an endovascular aneurysm repair-treated abdominal aortic aneurysm.

Methods: We reconstructed post-endovascular aneurysm repair computed tomography scans of patients treated with an AFX or Nellix EG creating post-implantation EG models. We examined 16 patients, 8 in each group.

HRI usability evaluation of interaction modes for a teleoperated agricultural robotic sprayer.

Teleoperation of an agricultural robotic system requires effective and efficient human-robot interaction. This paper investigates the usability of different interaction modes for agricultural robot teleoperation. Specifically, we examined the overall influence of two types of output devices (PC screen, head mounted display), two types of peripheral vision support mechanisms (single view, multiple views), and two types of control input devices (PC keyboard, PS3 gamepad) on observed and perceived usability of a teleoperated agricultural sprayer.