Publications by authors named "Xenia V Sergeeva"
The elimination of ground reaction force (support withdrawal) vastly affects slow postural muscles in terms of their regulation and structure. One of the effects of support withdrawal in this study was an immediate postural muscle inactivation, followed by the daily gradual development of spontaneous activity of the slow postural soleus muscle in response to rat hindlimb suspension to mimic space flight. The origin of this activity is somewhat akin to muscle spasticity after spinal cord injuries and is the result of KCC2 content decline in the spinal cord's motor neurons.
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- Skeletal muscle unloading, which can happen due to conditions like space flight or prolonged bed rest, leads to negative changes in muscle function, notably increased fatigue.
- The mechanisms behind this unloading-induced fatigue are complex and go beyond just muscle atrophy, involving both neurobiological and intramuscular factors.
- A significant change during unloading is the shift in muscle fiber types from fatigue-resistant slow fibers to faster glycolytic fibers, resulting in reduced mitochondrial density and disrupted signaling pathways, which ultimately contribute to higher fatigue levels.