Publications by authors named "Xenia Almodovar"
Article Synopsis
- The study explores how adipose tissue macrophages (ATMs) are linked to liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) and assesses the impact of altering ATMs in a mouse model of non-alcoholic steatohepatitis (NASH).
- Researchers analyzed adipose tissue and liver biopsies from 42 NAFLD patients, finding a correlation between increased pro-inflammatory ATMs and higher stages of liver fibrosis.
- Modulating ATMs through a specific treatment notably reduced inflammation and fibrosis progression in the experimental NASH model, suggesting a potential therapeutic approach for managing liver damage in NAFLD.
The NADPH oxidase NOX4 has been proposed as necessary for the apoptosis induced by the Transforming Growth Factor-beta (TGF-β) in hepatocytes and hepatocellular carcinoma (HCC) cells. However, whether NOX4 is required for TGF-β-induced canonical (SMADs) or non-canonical signals is not fully understood yet, neither its potential involvement in other parallel actions induced by TGF-β. In this work we have used CRISPR Cas9 technology to stable attenuate NOX4 expression in HCC cells.
View Article and Find Full Text PDFBackground & Aims: Ductular reaction expansion is associated with poor prognosis in patients with advanced liver disease. However, the mechanisms promoting biliary cell proliferation are largely unknown. Here, we identify neutrophils as drivers of biliary cell proliferation and the defective wound-healing response.
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