Combining metabolic flux analysis with proteomics to shed light on the metabolic flexibility: the case of Hildenborough.

Introduction: Hildenborough is a gram-negative anaerobic bacterium belonging to the sulfate-reducing bacteria that exhibits highly versatile metabolism. By switching from one energy mode to another depending on nutrients availability in the environments" it plays a central role in shaping ecosystems. Despite intensive efforts to study energy metabolism at the genomic, biochemical and ecological level, bioenergetics in this microorganism remain far from being fully understood.