Publications by authors named "Xavier Kesse"
Primary bone cancers commonly involve surgery to remove the malignant tumor, complemented with a postoperative treatment to prevent cancer resurgence. Studies on magnetic hyperthermia, used as a single treatment or in synergy with chemo- or radiotherapy, have shown remarkable success in the past few decades. Multifunctional biomaterials with bone healing ability coupled with hyperthermia property could thus be of great interest to repair critical bone defects resulting from tumor resection.
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- Recent advancements in bone cancer treatments have been driven by new biomaterials, particularly in managing small and accessible tumors through surgical removal and scaffolding.
- A novel heterostructured nanobiomaterial has been developed, featuring a bioactive glass shell and a superparamagnetic iron oxide core, aiming to enhance bone repair and target cancer cells with magnetic hyperthermia.
- Initial tests show that these core-shell nanoparticles have good heating capacity, rapid mineralization, and cytocompatibility with human stem cells, indicating their potential for effectively repairing bone defects after tumor resections while also aiding in cancer treatment.
Sol-gel-derived bioactive glass nanoparticles (BGNs) are fascinating materials for bone regeneration. In the literature, it can be found that their specific surface area and their calcium content (Ca/Si ratio) are the two key parameters impacting strongly the particles' bioactivity. Nevertheless, in most studies, bioactivity tests are performed on a series of materials where both the composition and the specific surface area are varied.
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- The study focused on how different synthesis parameters affect the structure and composition of nanosized binary bioactive glass particles using a modified Stöber process.
- The amount and timing of calcium nitrate addition were crucial, with optimal Ca insertion achieved when added after 3 hours into the reaction, balancing morphology and aggregation.
- An ideal Ca/Si atomic ratio of 2 was established, leading to stable particles with a composition of 0.9SiO-0.1CaO without compromising their stability.
Spin crossover cations have been successfully synthesized in the pores of a mesoporous robust Metal-Organic Framework (MOF) MIL-100(Al) through sequential introduction of Fe(iii) cations and a sal2trien ligand. The MIL-100(Al)@Fe(sal2trien) hybrid material retains its crystallinity and partial porosity compared to the parent MOF. The spin state of the Fe(sal2trien)+ cations can be modulated at room temperature through sorption of guest molecules, paving the way to the design of a new generation of sensors based on MOF@spin crossover complex solids.
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