[Mental health of primary care nurses during the Covid-19 pandemic: a longitudinal study].

In a weakened healthcare system, the mental health of healthcare workers has become a priority issue. The aim of this longitudinal study was to assess the mental health of primary care nurses during the Covid-19 pandemic, using a postal survey. Four validated self-report questionnaires were used.

Marital status and long-term cardiovascular risk in general population-RIFLE project (Italy).

Background: The impact of marital status on cardiovascular disease (CVD) remains controversial in the general population.

Aim: The present investigation sought to delineate the association between marital status and long-term major non-fatal and fatal CVD, along with all-cause mortality within the scope of the RIFLE project (Risk Factors and Life Expectancy).

Methods: We examined the incidences of CVD, including cerebrovascular accidents and coronary heart disease (CHD), as well as all-cause mortality.

Positive and negative viral associations in patients with acute respiratory tract infections in primary care: the ECOVIR study.

Introduction: Acute respiratory infections (ARIs) are the most common viral infections encountered in primary care settings. The identification of causal viruses is still not available in routine practice. Although new strategies of prevention are being identified, knowledge of the relationships between respiratory viruses remains limited.

Marital status and long-term cardiovascular risk in general population (Gubbio, Italy).

To investigate whether marital status is associated to long-term major fatal and non-fatal cardiovascular events in men and women from the Gubbio Population Study. The incidence of cardiovascular disease (CVD), including stroke and coronary heart disease (CHD) and CVD death together with all-cause mortality were analyzed. The analysis included 2832 persons (44% men, 54 ± 11 years old).

COVID-19 psychological impact in general practitioners: A longitudinal study.

Introduction: COVID-19 may have negatively impacted the mental health of front-line healthcare workers, including general practitioners (GPs). This study sought to assess the psychological impact (stress, burnout and self-efficacy) of the COVID-19 outbreak in French GPs.

Methods: We carried out a postal-based survey of all GPs who worked in the French region of Normandy (departments of Calvados, Manche and Orne) from the exhaustive database of the Union Régionale des Médecins libéraux (URML Normandie) as of 15th April 2020 (one month after the first French COVID-19 sanitary lockdown).

[General medicine and notification of adverse reactions: contributions of health insurance representatives].

Introduction: In order to reduce the under-reporting of adverse drug reactions (ADR) in general practice, the Caen Normandie regional pharmacovigilance center (CRPV) has implemented a training program for the French health insurance representatives (DAM) of the Manche department in order to raise awareness among general practitioners (GPs) to ADR reporting.

Purpose Of Research: During quarterly visits of DAM to GPs, the mode of operation and the value of pharmacovigilance reporting was presented. This pilot study presents the impact of these DAM visits to GPs in term of ADRs reporting quantification.

Prescriptions of antihypertensive drugs are influenced by the characteristics of general practitioners and their patients: a cross-sectional study in Normandy, France.

Introduction: Hypertension is associated with significant cardio-vascular morbi-mortality. However, hypertension control is low, especially in France. The reasons influencing general practitioners' (GPs) prescription of antihypertensive drugs (ADs) remains unclear.

The Design and Implementation of the ECOVIR Project: A Primary Health Care Surveillance System to Strengthen Co-Detection of Respiratory Viruses in Normandy.

Acute respiratory infections (ARIs) need to be better understood and treated, as they are critical to public health, especially during crises such as the SARS-CoV2 pandemic. These are the most abundant infections in the general population and are seen primarily in primary care by general practitioners (GPs). Many different viruses are involved, according to epidemic variations.

COVID-19 vaccines associated with vasovagal malaise: A retrospective study in two mass vaccination centers and analysis of the WHO pharmacovigilance database.

The association between COVID-19 vaccines and vasovagal malaise (VVM) has recently been reported in the literature. Our study aimed to describe COVID-19 vaccines associated VVM cases and to identify risk factors of COVID-19 vaccines associated VVM. To this end, we performed a descriptive study of VVM reports associated with COVID-19 vaccines from two French mass COVID-19 vaccination centers.

[Not Available].

Malgré leur prescription en seconde intention après les anticoagulants oraux directs, les antivitamines K (AVK) sont encore largement utilisés en soins premiers. En France, la fluindione représentait 82 % des AVK prescrits en 2016 contre 13 % pour la warfarine. Pourtant, la warfarine est l'AVK de référence ailleurs dans le monde et sa demi-vie plus longue devrait la rendre plus adaptée avec des International Normalized Ratio (INR) plus stables.

Relationship between lifestyle factors and hypertension: a cross-sectional analysis from the Gubbio study.

Background: Hypertension (HTN) is a well-established and a major risk factor for cardiovascular disease. Lifestyle behaviours for its prevention and control are recommended within worldwide guidelines. Their relationship with HTN need more investigations.

Professional practice for COVID-19 risk reduction among health care workers: A cross-sectional study with matched case-control comparison.

Background: Health care workers (HCWs) are particularly exposed to COVID-19 and therefore it is important to study preventive measures in this population.

Aim: To investigate socio-demographic factors and professional practice associated with the risk of COVID-19 among HCWs in health establishments in Normandy, France.

Methods: A cross-sectional and 3 case-control studies using bootstrap methods were conducted in order to explore the possible risk factors that lead to SARS-CoV2 transmission within HCWs.

Psychological impact of the COVID-19 outbreak in community pharmacists: A longitudinal study.

Background: Coronavirus disease 2019 (COVID-19) has negatively affected the mental health of frontline health care workers, including pharmacists.

Objectives: The aim of this longitudinal study was to assess the psychological impact of the COVID-19 outbreak in French owner community pharmacists.

Methods: We conducted a postal-based survey to assess the psychological difficulties of the COVID-19 outbreak in French owner community pharmacists based on 3 psychologically validated self-report questionnaires: Perceived Stress Scale (PSS), Impact of Event Scale-revised (IES-R), and Maslach Burnout Inventory.

Impact on mental health of the COVID-19 outbreak among general practitioners during the sanitary lockdown period.

Background: COVID-19 outbreak can impact mental health including health care workers.

Aim: The aim of this study was to assess the mental health impact of COVID-19 in French General Practitioners (GPs).

Methods: We carried out a postal-based survey during the first lockdown.

Impact of Sex on Office White Coat effect Tail: A Review.

Office white-coat effect tail (OWCET) is defined as a decrease of ≥10 mmHg in systolic blood pressure (SBP) between successive measurements after its waxing during an office visit. The influence of sex on the incidence of long-term major fatal and non-fatal cardiovascular events was studied in two Italian populational cohorts [from the Gubbio Study and the Italian Rural Areas of the Seven Countries Study (IRA)]. OWCET increased risk of cardiovascular disease (CVD) [HR: 1.

Perceived Cognitive Impairment in Breast Cancer Survivors and Its Relationships with Psychological Factors.

Cognitive complaints are common adverse effects in cancer patients. Identifying subjects at risk could make it possible to limit their impact. We aimed to explore the relationship between current cognitive complaints and demographic and psychological factors in a group of breast cancer survivors.

[INR and vitamin K antagonists management by the primary care physicians in Normandy].

The main objective of our study was to carry out a statement of the knowledge and the management of the VKA by the General Practitioners (GPs) of Normandy and to evaluate their experience of the use of DOA with a questionnaire; 471 of the 1951 GPs requested responded. When the INR was stable in a patient affected with atrial fibrillation, the GPs participating dosed it again 4 weeks later, modified the dosage when the INR was below 1.9 or upper 3.

Haematologic malignancies associated with clozapine all other antipsychotic agents: a pharmacovigilance study in VigiBase.

Background: Clozapine is mainly used in patients with treatment-resistant schizophrenia and may lead to potentially severe haematologic adverse events, such as agranulocytosis. Whether clozapine might be associated with haematologic malignancies is unknown. We aimed to assess the association between haematologic malignancies and clozapine using Vigibase®, the WHO pharmacovigilance database.

[Completeness of pharmacovigilance reporting in general medicine in France.].

Introduction: Spontaneous reporting remains one of the cornerstones of post-marketing drug safety surveillance. One of its main limitations is a lack of completeness.The main aim of this study was to assess the completeness of pharmacovigilance reports sent by general practitioners (GPs) to regional pharmacovigilance centers (RPC) reported in the French pharmacovigilance database (FPVD).

Impact of Sex on Office White Coat Effect Tail: Investigating Two Italian Residential Cohorts.

To assess the impact of sex on office white-coat effect tail (OWCET), the waning of systolic blood pressure (SBP) after its waxing during office visit, on the incidence of long-term major fatal and non-fatal events in two Italian residential cohorts [from the Gubbio Study and the Italian Rural Areas of the Seven Countries Study (IRA)]. There were 3565 persons (92 with missing data, 44% men, 54 ± 11 years) included in the Gubbio and 1712 men (49 ± 5 years) in the IRA studies. OWCET was defined as a decrease of ≥10 mmHg in SBP between successive measurements with slight measurement differences between the two cohorts.

White-coat hypertension: management and adherence to guidelines by European and Canadian GPs. A cross-sectional clinical vignette study.

Background: White-coat hypertension (WCH) is also referred to as 'isolated clinic hypertension'. While it is a frequently encountered phenomenon, WCH is not systematically evoked, and its management remains unclear due to the contradictory guidelines provided by professional societies.

Aim: To examine WCH management by GPs in Europe and Canada.