Publications by authors named "Xavier Halna du Fretay"

Article Synopsis
  • The study examines the occurrence and location of coronary artery disease (CAD) in adults with anomalous aortic origin of a coronary artery (AAOCA), which is not well documented.
  • Researchers analyzed data from 390 patients, focusing on the presence of CAD through imaging techniques like coronary angiography.
  • The findings revealed that CAD is more prevalent in the proximal segment of retroaortic AAOCA compared to other types of AAOCA, with no CAD found in the proximal segment of interarterial AAOCA, and the reasons for these differences remain unclear.
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Article Synopsis
  • Coronary aneurysms are rare bulges in the heart's arteries and can have different causes, but doctors don't know much about them yet because there aren't many studies.
  • The main way to check for these aneurysms is through a test called coronary angiography, but it can sometimes miss certain cases, while other imaging tools like intravascular ultrasound and coronary CT angiography can provide more detailed information.
  • Understanding and monitoring coronary aneurysms is important, and as scientists learn more, they hope to find better ways to manage and treat them.
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Intra coronary thrombus is  frequently encountered during acute coronary syndromes revascularisation procedures. It can also be encountered during angioplasty procedures in a stable angina context, although at a much lesser frequency.In both situations, it harbors a risk of poor angiographic result and poor prognosis.

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Background With the emergence of coronary computed tomography (CT) angiography, anomalous aortic origin of a coronary artery (ANOCOR) is more frequently diagnosed. Fractional flow reserve derived from CT (FFRCT) is a noninvasive functional test providing anatomical and functional evaluation of the overall coronary tree. These unique features of anatomical and functional evaluation derived from CT could help for the management of patients with ANOCOR.

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Objectives: Anomalous origin of the right coronary artery (ARCA) represents the most common form of abnormal coronary origin and may potentially increase the risk for sudden cardiac death. Morphological and functional evaluation of ARCA in adult patients referred for invasive coronary angiogram (ICA) is challenging. Quantitative flow ratio (QFR) is an available method able to virtually calculate fractional flow reserve using 3-dimensional quantitative coronary angiography (3D-QCA) based on ICA.

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Few patients with an anomalous aortic origin of a coronary artery (AAOCA) require a correction of this congenital anomaly. Current recommendations offer surgical repair as a first line therapy to prevent a sudden cardiac death as a main objective. However, these guidelines are focused on children and not based on randomized controlled studies.

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Objective: The diagnosis of anomalous connections of the coronary arteries (ANOCOR) requires an appropriate identification for the management of the patients involved. We studied the observer variability in the description and classification of ANOCOR between a nonexpert group of physicians and a group of expert physicians, using the ANOCOR cohort.

Patients And Design: Consecutive patients identified by 71 referring cardiologists were included in the ANOCOR cohort.

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Background: Elderly patients are at high risk of ischaemic and bleeding events. Platelet function monitoring offers the possibility to individualise antiplatelet therapy to improve the therapeutic risk-benefit ratio. We aimed to assess the effect of platelet function monitoring with treatment adjustment in elderly patients stented for an acute coronary syndrome.

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Background: We have been intrigued by the observation that aortic stenosis (AS) may be associated with characteristic features of mitral drug-induced valvular heart disease (DI-VHD) in patients exposed to valvulopathic drugs, thus suggesting that beyond restrictive heart valve regurgitation, valvulopathic drugs may be involved in the pathogenesis of AS.

Methods: Herein are reported echocardiographic features, and pathological findings encountered in a series of patients suffering from both AS (mean gradient >15mmHg) and mitral DI-VHD after valvulopathic drugs exposure. History of rheumatic fever, chest radiation therapy, systemic disease or bicuspid aortic valve disease were exclusion criteria.

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