Publications by authors named "Xavier Freixa-Rofastes"
A comparison of simplified or conventional antithrombotic regimens after left atrial appendage closure in patients at high bleeding risk: the PLATEBRISK study.
EuroIntervention
August 2024
Article Synopsis
- Antithrombotic treatment (ATT) after left atrial appendage occlusion (LAAO) is debated, especially for patients at high bleeding risk.
- This study compared simplified ATT, which involves single antiplatelet or no treatment, to conventional ATT, including dual antiplatelet or anticoagulation therapy, in very high bleeding risk patients.
- Results showed no significant differences in major adverse outcomes between the two treatment groups; however, patients with a history of major bleeding had a lower incidence of major bleeding with the simplified ATT.
Article Synopsis
- The study evaluated the effectiveness of the Vasopressor test (VPT) in patients with functional mitral regurgitation (MR) and left ventricular dysfunction undergoing transcatheter edge-to-edge repair (TEER).* -
- Out of 1115 patients, those who underwent VPT had higher rates of significant MR and greater overall mortality at one year compared to those who did not undergo the test, indicating a potentially higher risk profile.* -
- Despite the increased mortality rates in the VPT group, other key outcomes like heart failure readmissions and cardiovascular mortality showed no significant differences, suggesting VPT can aid in managing high-risk patients without worsening long-term outcomes.*
Prosthetic paravalvular leaks (PVLs) are associated with congestive heart failure and hemolysis. Surgical PVL closure carries high risks. Transcatheter implantation of occluding devices in PVL is a lower risk but challenging procedure.
View Article and Find Full Text PDFEndothelial cell dysfunction is the principal cause of several cardiovascular diseases that are increasing in prevalence, healthcare costs, and mortality. Developing a standardized, representative in vitro model of endothelial cell dysfunction is fundamental to a greater understanding of the pathophysiology, and to aiding the development of novel pharmacological therapies. We subjected human umbilical vein endothelial cells (HUVECs) to different periods of nutrient deprivation or increasing doses of HO to represent starvation or elevated oxidative stress, respectively, to investigate changes in cellular function.
View Article and Find Full Text PDFObjectives: This study aimed to investigate the feasibility and safety of left atrial appendage occlusion (LAAO) procedures in patients with persistent left atrial appendage (LAA) thrombus.
Background: The left atrial appendage (LAA) is the most common site of thrombus formation in patients with nonvalvular atrial fibrillation (AF). Oral anticoagulation (OAC) is used to prevent and treat AF-related thrombus.