Ghrelin Gene Variants Influence on Metabolic Syndrome Components in Aged Spanish Population.

Background: The role of genetic variations within the ghrelin gene on cardiometabolic profile and nutritional status is still not clear in humans, particularly in elderly people.

Objectives: We investigated six SNPs of the ghrelin gene and their relationship with metabolic syndrome (MS) components.

Subjects And Methods: 824 subjects (413 men/411 women, age 77.

Aging phenotype and its relationship with IGF-I gene promoter polymorphisms in elderly people living in Catalonia.

Objectives: Genetic variations in the Insulin/IGF-I genes pathway have been related to longevity, dementia, metabolic diseases and cancer. The purpose of the present study was to investigate the 192 bp allele of IGF-I gene promoter and its relationship with metabolic syndrome (MS) components, mental and nutritional state, muscle strength and functional capacity in an aged Spanish population.

Design: Population-based study (Mataró Ageing Study), including 292 subjects (144 men and 148 women, mean age 77.

Relationship between ghrelin and the metabolic syndrome in the elderly: a longitudinal population-based study.

Context: Ghrelin regulates energy homeostasis and may contribute to the development of the metabolic syndrome (MS) in the elderly.

Objective: To study the relationship between ghrelin and the MS, IGF-I and life style factors over a 2-year follow-up.

Design: Longitudinal population-based study, starting from 2002; 2 years follow-up.