Publications by authors named "Xavier Ara-Mancebo"
Article Synopsis
- Aggressive large B-cell lymphomas (LBCL) have diverse biological traits; detecting MYC rearrangements (MYCr) is crucial for understanding their prognosis.
- Current recommendations urge performing cytogenetic tests on all aggressive LBCL cases to identify MYCr, but due to its low occurrence, affordable screening options are necessary.
- Researchers developed a scoring system and algorithm based on immunohistochemical profiles of CD10, LMO2, and MYC to effectively screen for MYCr, achieving high sensitivity and predictive values in both training and validation series.
Background: is a relevant gene involved in B-cell ontogeny and a survival predictor of aggressive large B-cell lymphomas (aLBCL). Most studies assessing mRNA expression have relied on microarray platforms or qRT-PCR methods, overlooking tissue morphology. In this study, we evaluate RNA expression by chromogenic in situ hybridization (CISH) in normal tissue and in a series of 82 aLBCL.
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