Publications by authors named "Xaquin Gurriaran"
Background: Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the life span. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified.
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- *Research previously posited that certain genetic risk factors could have offered advantages in specific environments, but newer studies dispute the idea of positive selection for these risk factors.
- *The study used data from the 1000 Genomes Project to analyze how recent natural selection influenced schizophrenia-related genes, ultimately suggesting that non-antagonistic pleiotropy might explain the enduring presence of these genetic variations due to their links to other non-psychiatric traits.
Article Synopsis
- - The study explores how rare genetic mutations may link autism spectrum disorders (ASD) and epilepsy, despite common genetic variations showing no significant role in their comorbidity.
- - Researchers focused on the target genes of 14 specific miRNAs that are dysregulated in both conditions, finding a negative genetic correlation indicating that certain common variants may underlie the two disorders in distinct ways.
- - The findings suggest that analyzing miRNA regulatory networks can clarify the genetic complexity of ASD and its comorbidity with epilepsy, which contrasts with the stronger link suggested by clinical observations.
Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO.
View Article and Find Full Text PDFWhether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P = 0.
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- The study explores how genetic factors contribute to alcohol dependence, highlighting that high alcohol consumption and alcohol dependence have different genetic correlations with other psychiatric traits.
- Researchers analyzed data from 524 alcohol-dependent patients and 729 controls, calculating polygenic risk scores (PRS) to assess risks associated with alcohol use and various psychiatric disorders.
- Findings indicate that both general psychopathology (via the polygenic p factor) and high alcohol consumption are associated with alcohol dependence, suggesting that genetic risks can be divided into different components affecting this condition.
Genetic susceptibility to substance use disorders (SUDs) is partially shared between substances. Heritability of any substance dependence, estimated as 54%, is partly explained by additive effects of common variants. Comorbidity between SUDs and other psychiatric disorders is frequent.
View Article and Find Full Text PDFGenetics plays an important role in alcohol abuse/dependence. Its heritability has been estimated as 45-65%. Rare copy number variations (CNVs) have been confirmed as relevant genetic factors in other neuropsychiatric disorders, such as autism spectrum disorders, schizophrenia, epilepsy, or Tourette syndrome.
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