Publications by authors named "Xanthe Hoad"
Background: A vestibular schwannoma (VS) is a relatively rare, benign tumour of the eighth cranial nerve, often involving alterations to the gene NF2. Previous mathematical models of schwannoma incidence have not attempted to account for alterations in specific genes, and could not distinguish between nonsense mutations and loss of heterozygosity (LOH).
Methods: Here, we present a mechanistic approach to modelling initiation and malignant transformation in schwannoma.