Publications by authors named "Xanne M Miggelbrink"
Article Synopsis
- Monocytes are vital for the immune system, and this study investigates how chromatin remodeling affects their differentiation into various effector cell types, particularly dendritic cells.
- The research identifies that the lysine methyltransferase KMT1c is notably upregulated during the differentiation of monocytes into immature dendritic cells (iDCs), and inhibiting KMT1c alters transcription of the DC marker DC-SIGN.
- The findings suggest that KMTs play a crucial role in monocyte-derived dendritic cell differentiation, highlighting the potential of KMT inhibitors in epigenetic immune therapies, which traditionally focus on HDAC inhibitors.
