Topical calcipotriol for preventive treatment of hypertrophic scars: a randomized, double-blind, placebo-controlled trial.

Objectives: To evaluate the efficacy of topical application of calcipotriol to healing wounds in preventing or reducing hypertrophic scar formation and to investigate the biochemical properties of the epidermis associated with hypertrophic scar formation.

Design: Randomized, double-blind, placebo-controlled trial using the reduction mammoplasty wound-healing model.

Setting: University Medical Center Groningen.