Association of Lipids With Ischemic and Hemorrhagic Stroke: A Prospective Cohort Study Among 267 500 Chinese.

Background and Purpose- Previous results on the association between lipids and stroke were controversial. We investigated the association of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C ), high-density lipoprotein cholesterol (HDL-C), and triglyceride with stroke. Methods- Six cohort studies in China with 267 500 participants were included.

One-Year Home-Time and Mortality After Thrombolysis Compared With Nontreated Patients in a Propensity-Matched Analysis.

Background and Purpose- Intravenous thrombolysis with r-tPA (recombinant tissue-type plasminogen activator) is associated with improved early functional outcome after stroke, but its long-term effects are less understood. We aimed to determine the association between r-tPA and 1-year outcomes after stroke. Methods- We used the Ontario Stroke Registry to identify patients diagnosed with ischemic stroke between 2002 and 2013 in Ontario, Canada, their baseline characteristics, and whether they received r-tPA.

Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits.

Background: Transgenic mouse studies suggest that γ-aminobutyric acid type A (GABAA) receptors containing β3 subunits mediate important effects of etomidate, propofol, and pentobarbital. Zebrafish, recently introduced for rapid discovery and characterization of sedative-hypnotics, could also accelerate pharmacogenetic studies if their transgenic phenotypes reflect those of mammals. The authors hypothesized that, relative to wild-type, GABAA-β3 functional knock-out (β3) zebrafish would show anesthetic sensitivity changes similar to those of β3 mice.

Enhanced Cycling Performance of Ni-Rich Positive Electrodes (NMC) in Li-Ion Batteries by Reducing Electrolyte Free-Solvent Activity.

The interfacial (electro)chemical reactions between electrode and electrolyte dictate the cycling stability of Li-ion batteries. Previous experimental and computational results have shown that replacing Mn and Co with Ni in layered LiNiMnCoO (NMC) positive electrodes promotes the dehydrogenation of carbonate-based electrolytes on the oxide surface, which generates protic species to decompose LiPF in the electrolyte. In this study, we utilized this understanding to stabilize LiNiMnCoO (NMC811) by decreasing free-solvent activity in the electrolyte through controlling salt concentration and salt dissociativity.

Younger Age and Depressive Symptoms Predict High Risk of Generalized Anxiety After Stroke and Transient Ischemic Attack.

Background and Purpose- Depression and anxiety are common after stroke/transient ischemic attack (TIA). These conditions are associated with poor functional outcome and worse quality of life. However, few studies have explored predictors of poststroke risk of generalized anxiety, especially in patients without comorbid depressive symptoms.

Predicting 10-Year and Lifetime Stroke Risk in Chinese Population.

Background and Purpose- Risk assessment is essential for the primary prevention of stroke. However, the current available tools derived from Chinese populations are insufficient for individualized 10-year and lifetime stroke risk prediction. Our study aims to develop and validate personalized 10-year and lifetime stroke risk equations incorporating 4 large Chinese cohorts.

Quantitative tooth mobility evaluation based on intraoral scanner measurements.

Background: Tooth mobility assessment is subjective and current techniques require the translation of a continuous variable to a categorical variable based on the perception of the examiner. The aim of this study was to evaluate the reliability of a novel technique to assess tooth mobility.

Methods: Three experienced periodontists were asked to push tooth #16 into a buccal position to in a typodont model with different mobility (M1-M2).

Sparse Representation based Video Quality Assessment for Synthesized 3D Videos.

The temporal flicker distortion is one of the most annoying noises in synthesized virtual view videos when they are rendered by compressed multi-view video plus depth in Three Dimensional (3D) video system. To assess the synthesized view video quality and further optimize the compression techniques in 3D video system, objective video quality assessment which can accurately measure the flicker distortion is highly needed. In this paper, we propose a full reference sparse representation based video quality assessment method towards synthesized 3D videos.

Chromatography and mass spectrometry-based approaches for perception of polysaccharides in wild and cultured fruit bodies of Auricularia auricular-judae.

Auricularia auricular-judae polysaccharides (AAPs) have been accepted as one important biological constituent. Quality analysis of A. auricular-judae is generally difficult due to technical issues in separating and detecting AAPs.

Hierarchical Nanoassembly of MoS/CoS/NiS/Ni as a Highly Efficient Electrocatalyst for Overall Water Splitting in a Wide pH Range.

The design of low-cost yet high-efficiency electrocatalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) over a wide pH range is highly challenging. We now report a hierarchical co-assembly of interacting MoS and CoS nanosheets attached on NiS nanorod arrays which are supported on nickel foam (NF). This tiered structure endows high performance toward HER and OER over a very broad pH range.

MRI-guided robotic arm drives optogenetic fMRI with concurrent Ca recording.

Optical fiber-mediated optogenetic activation and neuronal Ca recording in combination with fMRI provide a multi-modal fMRI platform. Here, we developed an MRI-guided robotic arm (MgRA) as a flexible positioning system with high precision to real-time assist optical fiber brain intervention for multi-modal animal fMRI. Besides the ex vivo precision evaluation, we present the highly reliable brain activity patterns in the projected basal forebrain regions upon MgRA-driven optogenetic stimulation in the lateral hypothalamus.

MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.

Objective: MARK4 (microtubule affinity-regulating kinase 4) regulates NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome activation. The aim of the study is to examine the role of MARK4 in hematopoietic cells during atherosclerosis.

Methods And Results: We show increased MARK4 expression in human atherosclerotic lesions compared with adjacent areas.

Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart.

Rationale: Replication-independent histone turnover has been linked to cis-regulatory chromatin domains in cultured cell lines, but its molecular underpinnings and functional relevance in adult mammalian tissues remain yet to be defined.

Objective: We investigated regulatory functions of replication-independent histone turnover in chromatin states of postmitotic cardiomyocytes from adult mouse heart.

Methods And Results: We used H2B-GFP (histone 2B-green fluorescent protein) fusion protein pulse-and-chase approaches to measure histone turnover rate in mouse cardiomyocytes.

Long-Term Exposure to Fine Particulate Matter and Hypertension Incidence in China.

The risk of incident hypertension associated with long-term exposure to fine particulate matter (PM) was still unclear by studies conducted in North America and Europe, and this relationship has rarely been quantified at higher ambient concentrations typically found in developing countries. We aimed to investigate the association between PM and incident hypertension using the large-scale prospective cohorts in China. We included 59 456 participants without hypertension aged ≥18 years from the China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) project.

Assessment of microvasculature flow state with a high speed all-optic dual-modal system of optical coherence tomography and photoacoustic imaging.

We propose a high speed all-optic dual-modal system that combines spectral domain optical coherence tomography (SDOCT) and photoacoustic imaging (PAI) to evaluate microvasculature flow states. A homodyne interferometer was used to remotely detect the surface vibration caused by photoacoustic (PA) waves. The PA excitation, PA probing and SDOCT probing beams share the same X-Y galvanometer scanner to perform fast two-dimensional scanning.

A safe and potent anti-CD19 CAR T cell therapy.

Anti-CD19 chimeric antigen receptor (CAR) T cell therapies can cause severe cytokine-release syndrome (CRS) and neurotoxicity, impeding their therapeutic application. Here we generated a new anti-CD19 CAR molecule (CD19-BBz(86)) derived from the CD19-BBz prototype bearing co-stimulatory 4-1BB and CD3ζ domains. We found that CD19-BBz(86) CAR T cells produced lower levels of cytokines, expressed higher levels of antiapoptotic molecules and proliferated more slowly than the prototype CD19-BBz CAR T cells, although they retained potent cytolytic activity.

Preparation and Performance of the Heterostructured Material with a Ni-Rich Layered Oxide Core and a LiNiMnO-like Spinel Shell.

The LiNiCo Al O (NCA)-layered materials are regarded as a research focus of power lithium-ion batteries (LIBs) because of their high capacity. However, NCA materials are still up against the defects of cation mixing and surface erosion of electrolytes. Herein, a novel design strategy is proposed to obtain a heterostructured cathode material with a high-capacity LiNiCoAlO layer ( R3̅ m) core and a stable LiNiMnO-like spinel ( Fd3̅ m) shell, which is prepared through spontaneous redox reaction of the precursor with KMnO in an alkaline solution and subsequent calcination procedure.

Three-dimensional porous graphene oxide-maize amylopectin composites with controllable pore-sizes and good adsorption-desorption properties: Facile fabrication and reutilization, and the adsorption mechanism.

Three-dimensional (3D) porous graphene oxide-maize amylopectin (GO-MA) composites with controllable pore-sizes composites in the range of 6-40 nm were prepared by facile hydrothermal-assisted assembly approaches. The morphologies, pore sizes, specific surface area (SSA) and compositions of GO-MA composites with and different GO-to-MA mass ratios (x:y) were characterized by scanning electron microscopy (SEM), N adsorption-desorption isotherms, Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). To reveal the adsorption-desorption mechanism, effects of contact time, temperature, initial adsorbate concentration, pH value of the solution on the adsorption process were studied in detail.

Intrauterine exposure to hyperglycemia retards the development of brown adipose tissue.

Brown adipose tissue (BAT) is an exclusive tissue of nonshivering thermogenesis. It is fueled by lipids and glucose and involved in energy and metabolic homeostasis. Intrauterine exposure to hyperglycemia during gestational diabetes mellitus may result in abnormal fetal development and metabolic phenotypes in adulthood.

Increased Risk of Traffic Injury After a Cerebrovascular Event.

Background and Purpose- We aimed to determine the long-term risks of a motor vehicle collision after a cerebrovascular event and whether the risks were similar after left- or right-hemispheric events. Methods- We used a population-based registry to identify patients diagnosed with a transient ischemic attack or stroke (hemorrhagic or ischemic) between 2003 and 2013 in Ontario, Canada. Hemispheric laterality was determined using radiological and clinical findings.

Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation.

Background: Human loss-of-function variants of ANK2 (ankyrin-B) are linked to arrhythmias and sudden cardiac death. However, their in vivo effects and specific arrhythmogenic pathways have not been fully elucidated.

Methods: We identified new ANK2 variants in 25 unrelated Han Chinese probands with ventricular tachycardia by whole-exome sequencing.

SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis.

Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and clinical outcomes, as well as their potential interactions with environmental risk factors, remain unclear. These issues are addressed here in a large Chinese CP cohort.

Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment.

Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions.

[Human action and road condition recognition based on the inertial information].

Rapid and accurate recognition of human action and road condition is a foundation and precondition of implementing self-control of intelligent prosthesis. In this paper, a Gaussian mixture model and hidden Markov model are used to recognize the road condition and human motion modes based on the inertial sensor in artificial limb (lower limb). Firstly, the inertial sensor is used to collect the acceleration, angle and angular velocity signals in the direction of , and axes of lower limbs.