In Situ Generation of NiCoP Nanoparticles on a Bimetal-Organic Framework for High-Performance Supercapacitors.

The rational exploration of hybrid materials with well-defined compositions and structures/morphologies is essential for achieving high-performance electrodes for supercapacitors. Here, in situ dispersion and anchoring of NiCoP nanoparticles (NPs) on a bimetal-organic framework (CoNi-MOF) by a controllable partial phosphorization approach are reported. The phosphating temperature and time significantly affect the specific capacitance of NiCoP/CoNi-MOF-- (where and represent the phosphating temperature and time, respectively).

Safety and immunogenicity of a hybrid-type vaccine booster in BBIBP-CorV recipients in a randomized phase 2 trial.

NVSI-06-08 is a potential broad-spectrum recombinant COVID-19 vaccine that integrates the antigens from multiple SARS-CoV-2 strains into a single immunogen. Here, we evaluate the safety and immunogenicity of NVSI-06-08 as a heterologous booster dose in BBIBP-CorV recipients in a randomized, double-blind, controlled, phase 2 trial conducted in the United Arab Emirates (NCT05069129). Three groups of healthy adults over 18 years of age (600 participants per group) who have administered two doses of BBIBP-CorV 4-6-month, 7-9-month and >9-month earlier, respectively, are randomized 1:1 to receive either a homologous booster of BBIBP-CorV or a heterologous booster of NVSI-06-08.

Carbon-Based Modification Materials for Lithium-ion Battery Cathodes: Advances and Perspectives.

Lithium-ion batteries (LIBs) have attracted great attention as an advanced power source and energy-storage device for years due to their high energy densities. With rapid growing demands for large reversible capacity, high safety, and long-period stability of LIBs, more explorations have been focused on the development of high-performance cathode materials in recent decades. Carbon-based materials are one of the most promising cathode modification materials for LIBs due to their high electrical conductivity, large surface area, and structural mechanical stability.

Airway Eosinophilia on Bronchoalveolar Lavage and the Risk of Exacerbations in COPD.

The associations between airway eosinophilia, measured in sputum or peripheral blood, and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are inconsistent. We therefore aimed to determine the association between eosinophilia in bronchoalveolar lavage (BAL) fluid and AECOPD in a clinical cohort. We analyzed differential cell counts from baseline BAL fluid in participants in the DISARM clinical trial (Clinicaltrials.

Accurate Adjusting the Lattice Strain of Triple-Cation and Mixed-Halide Perovskites for High-Performance Photodetector.

The instability of perovskite optoelectronic devices remains a big barrier to their commercialization. The instability caused by external stimuli has been addressed by encapsulation, such as humidity, oxygen, heat, and ultraviolet light. However, the intrinsic instability of perovskite materials due to the lattice strain has not been fully addressed, which affects the physical properties and device performance to a great extent.

Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na/H Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.

Background: The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.

Methods: Adult intestine-specific -knockout mice ( ) and Dahl salt-sensitive rats were studied on the effect of high salt intake (8% NaCl, 6-7 weeks) on intestinal NaH exchanger 3 expression, urine sodium concentration, and blood pressure. High-salt diet increased urine sodium concentration and systolic blood pressure to a greater extent in mice and Dahl salt-sensitive rats than their respective controls, mice and SS13 rats.

Stoichiometry design in hierarchical CoNiFe phosphide for highly efficient water oxidation.

Unlabelled: Rational composition design of trimetallic phosphide catalysts is of significant importance for enhanced surface reaction and efficient catalytic performance. Herein, hierarchical Co Ni Fe P with precise control of stoichiometric metallic elements ( = (1-10):(1-10):1) has been synthesized, and CoNiFeP, as the most optimal composition, exhibits remarkable catalytic activity ( = 320 mV at 10 mA cm) and long-term stability (ignorable decrease after 10 h continuous test at the current density of 10 mA cm) toward oxygen evolution reaction (OER). It is found that the surface P in CoNiFeP was replaced by O under the OER process.

Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV: a phase 2 trial.

The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine (BBIBP-CorV) followed by a recombinant protein-based vaccine (NVSI-06-07), using homologous boost with BBIBP-CorV as control. Three groups of healthy adults (600 individuals per group) who had completed two-dose BBIBP-CorV vaccinations 1-3 months, 4-6 months and ≥6 months earlier, respectively, were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.

Chemotherapy combined with immunotherapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). We conducted a randomized phase 2 trial evaluating the efficacy of nivolumab (nivo; anti-PD-1) and/or sotigalimab (sotiga; CD40 agonistic antibody) with gemcitabine/nab-paclitaxel (chemotherapy) in patients with first-line metastatic PDAC ( NCT03214250 ). In 105 patients analyzed for efficacy, the primary endpoint of 1-year overall survival (OS) was met for nivo/chemo (57.

Endovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry.

Background: The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO).

Methods: The present analysis was based on the ongoing, prospective, multicenter ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) trial registry in China. Our analytic sample comprised 2134 patients recruited at 48 sites between 2017 and 2021 and included 462 patients who received BMM and 1672 patients who received EVT.

Carotid Siphon Calcification Predicts the Symptomatic Progression in Branch Artery Disease With Intracranial Artery Stenosis-Brief Report.

Background: Arterial calcification in the aortic arch, carotid bifurcation, or siphon on computed tomography was associated with cardiovascular disease. The association between arterial calcification prevalence and progression of branch atheromatous disease (BAD) in intracranial artery atherosclerosis was little investigated.

Methods: This study included 310 patients with ischemic stroke from one stroke center.

Impact of the Arbuscular Mycorrhizal Fungus on the Physiological and Defence Responses of to Copper Oxide Nanoparticles Stress.

Copper oxide nanoparticles (nano-CuO) are recognized as an emerging pollutant. Arbuscular mycorrhizal fungi (AMF) can mitigate the adverse impacts of various pollutants on host plants. However, AMF's mechanism for alleviating nano-CuO phytotoxicity remains unclear.

Sodium Pentobarbital Suppresses Breast Cancer Cell Growth Partly via Normalizing Microcirculatory Hemodynamics and Oxygenation in Tumors.

Breast cancer remains the leading cause of cancer-related death among women worldwide. Sodium pentobarbital was found to play an inhibitory role in glioma growth in rats. In this study, we aimed to evaluate the effects of sodium pentobarbital on breast cancer growth both in vitro and in vivo, and its impacts on the microcirculatory changes on both skin and tumor surface in mice bearing subcutaneous xenograft.

Association between Chest CT-defined Emphysema and Lung Cancer: A Systematic Review and Meta-Analysis.

Background Given the different methods of assessing emphysema, controversy exists as to whether it is associated with lung cancer. Purpose To perform a systematic review and meta-analysis of the association between chest CT-defined emphysema and the presence of lung cancer. Materials and Methods The PubMed, Embase, and Cochrane databases were searched up to July 15, 2021, to identify studies on the association between emphysema assessed visually or quantitatively with CT and lung cancer.

Constructing Hydrophobic Interface with Close-Packed Coordination Supramolecular Network for Long-Cycling and Dendrite-Free Zn-Metal Batteries.

Commercialization of aqueous zinc-metal batteries remains unrealistic due to the substantial dendrite growth and side reaction issues on the zinc anodes. It is highly demanded to develop easy-to-handle approaches for constructing stable, dense, as well as homogeneous solid anode/electrolyte interfaces. Herein, the authors construct the zinc anode interface with a close-packed Zn-TSA (TSA = thiosalicylate) coordination supramolecular network through the facile and up-scalable wet-chemical method.

Using High-Entropy Configuration Strategy to Design Na-Ion Layered Oxide Cathodes with Superior Electrochemical Performance and Thermal Stability.

Na-ion layered oxide cathodes (NaTMO, TM = transition metal ion(s)), as an analogue of lithium layered oxide cathodes (such as LiCoO, LiNiCoMnO), have received growing attention with the development of Na-ion batteries. However, due to the larger Na radius and stronger Na-Na electrostatic repulsion in NaO slabs, some undesired phase transitions are observed in NaTMO. Herein, we report a high-entropy configuration strategy for NaTMO cathode materials, in which multicomponent TMO slabs with enlarged interlayer spacing help strengthen the whole skeleton structure of layered oxides through mitigating Jahn-Teller distortion, Na/vacancy ordering, and lattice parameter changes.

Angle-tuned coils: attractive building blocks for TMS with improved depth-spread performance.

A novel angle-tuned ring coil is proposed for improving the depth-spread performance of transcranial magnetic stimulation (TMS) coils and serve as the building blocks for high-performance composite coils and multisite TMS systems.Improving depth-spread performance by reducing field divergence through creating a more elliptical emitted field distribution from the coil. To accomplish that, instead of enriching the Fourier components along the planarized () directions, which requires different arrays to occupy large brain surface areas, we worked along the radial () direction by using tilted coil angles and stacking coil numbers to reduce the divergence of the emitted near field without occupying large head surface areas.

Abundant topological phases in hydrogenated group-IV binary alloy compounds.

Based on the widely studied two-dimensional layered materials, new materials with unique properties can be acquired by stacking the layered materials with different styles. By using density-functional calculations and symmetry analysis, we here present a route to produce abundant topologically nontrivial electronic states in three-dimensional compounds made of stacked monolayer hydrogenated group-IV binary alloys. Triply degenerate point (TDP) semimetals and Dirac semimetals are found in the hydrogenated SnPb compounds with different stacking configurations.

Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS.

Background: Cerebral small vessel injury, including loss of endothelial tight junctions, endothelial dysfunction, and blood-brain barrier breakdown, is an early and typical pathology for Alzheimer's disease, cerebral amyloid angiopathy, and hypertension-related cerebral small vessel disease. Whether there is a common mechanism contributing to these cerebrovascular alterations remains unclear. Studies have shown an elevation of BACE1 (β-site amyloid precursor protein cleaving enzyme 1) in cerebral vessels from cerebral amyloid angiopathy or Alzheimer's disease patients, suggesting that vascular BACE1 may involve in cerebral small vessel injury.

Dictating the interfacial stability of nickel-rich LiNiCoMnO via a diazacyclo electrolyte additive - 2-Fluoropyrazine.

Nickel-rich (Ni-rich) cathode materials, LiNiCoMnO (NCM, x ≥ 0.9, x + y + z = 1) hold great promise for developing high energy density lithium ion batteries especially for vehicle electrification. However, the practical application of Ni-rich cathode materials is still suffered from fast structural and interfacial degradation, and the resulted capacity decay.

Three-Dimensional Digital Image Analysis of Skeletal and Soft Tissue Points A and B after Orthodontic Treatment with Premolar Extraction in Bimaxillary Protrusive Patients.

Aim. To investigate the effect of changes in incisor tip, apex movement, and inclination on skeletal points A and B and characterize changes in skeletal points A and B to the soft tissue points A and B after incisor retraction in Angle Class I bimaxillary dentoalveolar protrusion. Methods.

Preparation and Characterization of the Halogen-Bonding Motif in the Isolated Cl·IOH Complex with Cryogenic Ion Vibrational Spectroscopy.

In the presence of a halide ion, hypohalous acids can adopt two binding motifs upon formation of the ion-molecule complexes [XHOY] (X, Y = Cl, Br, I): a hydrogen (HB) bond to the acid OH group and a halogen (XB) bond between the anion and the acid halogen. Here we isolate the X-bonded Cl·IOH ion-molecule complex by collisions of I·(HO) clusters with HOCl vapor and measure its vibrational spectrum by IR photodissociation of the H-tagged complex. Anharmonic analysis of its vibrational band pattern reveals that formation of the XB complex results in dramatic lowering of the HOI bending fundamental frequency and elongation of the O-I bond (by 168 cm and 0.

Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease.

Antimicrobial resistance is a global concern in chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD). The collection of antibiotic resistance genes or resistome in human airways may underlie the resistance. COPD is heterogeneous, and understanding the airway resistome in relation to patient phenotype and endotype may inform precision antibiotic therapy.

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A.

Background: Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)-based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective promoter. The efficacy and safety of the therapy were previously evaluated in men with severe hemophilia A in a phase 1-2 dose-escalation study.

Methods: We conducted an open-label, single-group, multicenter, phase 3 study to evaluate the efficacy and safety of valoctocogene roxaparvovec in men with severe hemophilia A, defined as a factor VIII level of 1 IU per deciliter or lower.

Clinical and genomic features of Chinese lung cancer patients with germline mutations.

The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs.