Tungsten and Boron Codoping toward High Ionic Conductivity and Stable Sodium Solid Electrolyte for All-Solid-State Sodium Batteries.

Sodium solid electrolytes with high ionic conductivity and good interfacial stability with sodium metal are crucial to realize high-performance all-solid-state sodium batteries. In this work, W and B-codoped NaSbWSB solid electrolytes are prepared by melt-quenching with further annealing. The synthesized NaSbWSB solid electrolyte possesses a high ionic conductivity of 11.

ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by Targeting the Endo-Lysosomal Degradation of EGFR.

Background: Cardiac hypertrophy and subsequent heart failure impose a considerable burden on public health worldwide. Impaired protein degradation, especially endo-lysosome-mediated degradation of membrane proteins, is associated with cardiac hypertrophy progression. CHMP4C (charged multivesicular body protein 4C), a critical constituent of multivesicular bodies, is involved in cellular trafficking and signaling.

Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease.

Background: Tertiary lymphoid organs (TLOs) are ectopic lymphoid organs developed in nonlymphoid tissues with chronic inflammation, but little is known about their existence in different types of vascular diseases and the mechanism that mediated their development.

Methods: To take advantage of single-cell RNA sequencing techniques, we integrated 28 single-cell RNA sequencing data sets containing 5 vascular disease models (atherosclerosis, abdominal aortic aneurysm, intimal hyperplasia, isograft, and allograft) to explore TLOs existence and environment supporting its growth systematically. We also searched Medline, Embase, PubMed, and Web of Science from inception to January 2022 for published histological images of vascular remodeling for histological evidence to support TLO genesis.

Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity.

Background: Doxorubicin is an effective chemotherapy drug for treating various types of cancer. However, lethal cardiotoxicity severely limits its clinical use. Recent evidence has indicated that aberrant activation of the cytosolic DNA-sensing cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-STING (stimulator of interferon genes) pathway plays a critical role in cardiovascular destruction.

CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke.

Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Prediction of penumbra existence after AIS is crucial for making decision on reperfusion therapy. Yet a fast, inexpensive, simple, and noninvasive predictive biomarker for the poststroke penumbra with clinical translational potential is still lacking.

Mesoporous CdZnS with abundant surface defects for efficient photocatalytic hydrogen production.

The practical application of photocatalytic water splitting for hydrogen evolution hinges on the development of high-efficient and low-cost photocatalysts. Defects engineering has emerged as a promising strategy to enhance photocatalytic activity effectively. Herein, a facile and versatile co-precipitation method is proposed to fabricate mesoporous Cd-Zn-S solid solutions (E-CdZnS) with abundant surface defects by the inorganic salts formed in the reaction system as self-template.

Improved SERS activity of non-stoichiometric copper sulfide nanostructures related to charge-transfer resonance.

The low enhancement factor of semiconductor SERS substrates is a major obstacle for their practical application. Therefore, there is a need to explore the facile synthesis of new SERS substrates and reveal the SERS enhancement mechanism. Here, we develop a simple, facile and low-cost two-step method to synthesize copper sulfide based nanostructures with different CuS contents.

Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model.

The optical attenuation coefficient (OAC) estimated using optical coherence tomography (OAC-OCT) offers a label-free 3D mapping of tissue infarction, but the physiological origin of the OAC contrast remains unclear. For effectively suppressing OAC fluctuations, we propose a hybrid (wavelength/angle) division multiplexing (HDM) method, which improved the OAC contrast by 70.7% in tissue phantoms.

New metal chalcogenides found in Mn(GdIn)S (N = 3, 4, 5): syntheses, structures, and magnetic properties.

Three new metal chalcogenides have been identified in Mn(GdIn)S with N = 3, 4, and 5 via a flux-growth synthesis. All compounds crystallize in the same space group of orthorhombic Cmcm with cell constants: MnGdInS (1), a = 3.789(1) Å, b = 12.

[Research on diagnosis of gas-liquid detonation exhaust based on double optical path absortion spectroscopy technique].

The effect detection of detonation exhaust can provide measurement data for exploring the formation mechanism of detonation, the promotion of detonation efficiency and the reduction of fuel waste. Based on tunable diode laser absorption spectroscopy technique combined with double optical path cross-correlation algorithm, the article raises the diagnosis method to realize the on-line testing of detonation exhaust velocity, temperature and H2O gas concentration. The double optical path testing system is designed and set up for the valveless pulse detonation engine with the diameter of 80 mm.

[Comparison of soil respiration in natural Castanopsis carlesii forest and plantation forest].

By using the Li-8100 open soil carbon flux system, the dynamic change of soil respiration rate in natural Castanopsis carlesii and plantation of Castanopsis carlesii forests in Geshikao Nature Reserve in Fujian Province of China were measured from January 2011 to December 2011, with the relationship between the dynamic changes and the relation affecting factors analyzed. The monthly variation of soil respiration in the two types of forests were both single-peaked,with the peaks appeared in early June [7.03 micromol x (m2 x s) (-1)] andlate July [5.

A new class of lithium and sodium rechargeable batteries based on selenium and selenium-sulfur as a positive electrode.

A new class of selenium and selenium-sulfur (Se(x)S(y))-based cathode materials for room temperature lithium and sodium batteries is reported. The structural mechanisms for Li/Na insertion in these electrodes were investigated using pair distribution function (PDF) analysis. Not only does the Se electrode show promising electrochemical performance with both Li and Na anodes, but the additional potential for mixed Se(x)S(y) systems allows for tunable electrodes, combining the high capacities of S-rich systems with the high electrical conductivity of the d-electron containing Se.

[The effects of extrinsic positive end-expiratory pressure on work of breathing in patients with chronic obstructive pulmonary disease].

Objective: To study the effect of extrinsic positive end-expiratory pressure(PEEPe) on work of breathing in chronic obstructive pulmonary disease (COPD) patients and its mechanism.

Methods: 10 ventilated patients [4 males and 6 females with mean age of (70.1 +/- 5.

Nitric oxide inhalation in the treatment of right ventricular dysfunction following left ventricular assist device implantation.

Background: Following left ventricular assist device (LVAD) implantation in end-stage heart failure, the management of right ventricular dysfunction presents a therapeutic problem unresolved by conventional drug therapy (catecholamines, nitrates, and prostacyclin). This study was performed to investigate the effects of supplemental inhalation of nitric oxide (NO), a selective pulmonary vasodilator, postoperatively and prospectively.

Methods And Results: Intraindividual dose titration of NO was performed (0 to 40 ppm) according to a standardized protocol.