Deep Learning to Simulate Contrast-Enhanced MRI for Evaluating Suspected Prostate Cancer.

Background Multiparametric MRI, including contrast-enhanced sequences, is recommended for evaluating suspected prostate cancer, but concerns have been raised regarding potential contrast agent accumulation and toxicity. Purpose To evaluate the feasibility of generating simulated contrast-enhanced MRI from noncontrast MRI sequences using deep learning and to explore their potential value for assessing clinically significant prostate cancer using Prostate Imaging Reporting and Data System (PI-RADS) version 2.1.

High-capacity, fast-charging and long-life magnesium/black phosphorous composite negative electrode for non-aqueous magnesium battery.

Secondary non-aqueous magnesium-based batteries are a promising candidate for post-lithium-ion battery technologies. However, the uneven Mg plating behavior at the negative electrode leads to high overpotential and short cycle life. Here, to circumvent these issues, we report the preparation of a magnesium/black phosphorus (Mg@BP) composite and its use as a negative electrode for non-aqueous magnesium-based batteries.

Arrayed metal phosphide heterostructure by Fe doping for robust overall water splitting.

Transition metal phosphides (TMPs) show promise in water electrolysis due to their electronic structures, which activate hydrogen/oxygen reaction intermediates. However, TMPs face limitations in catalytic efficiency due to insufficient active sites, poor conductivity, and multiple intermediate steps in water electrolysis. Here, we synthesize a highly efficient bifunctional self-supported electrocatalyst, which consists of an N-doped carbon shell anchored on Fe-doped CoP/CoP arrays on nickel foam (NC@Fe-CoP/NF) using hydrothermal and phosphorization techniques.

Characterizations of Protein Arginine Deiminase 1 as a Substrate of NTMT1: Implications of Nα-Methylation in Protein Stability and Interaction.

α-N-Methylation (Nα-methylation), catalyzed by protein N-terminal methyltransferases (NTMTs), constitutes a crucial post-translational modification involving the transfer of a methyl group from -adenosyl-l-methionine (SAM) to the Nα-terminal amino group of substrate proteins. NTMT1/2 are known to methylate canonical Nα sequences, such as X-P-K/R. With over 300 potential human protein substrates, only a small fraction has been validated, and even less is known about the functions of Nα-methylation.

Capillary-Driven Separate Gas-Liquid Transport: Alleviating Mass Transport Losses for Efficient Hydrogen Evolution.

Developing earth-abundant transition metal electrodes with high activity and durability is crucial for efficient and cost-effective hydrogen production. However, numerous studies in the hydrogen evolution reaction (HER) primarily focus on improving the inherent activity of catalysts, and the critical influence of gas-liquid countercurrent transport behavior is often overlooked. In this study, we introduce the concept of separate-path gas-liquid transport to alleviate mass transport losses for the HER by developing a novel hierarchical porous Ni-doped cobalt phosphide electrode (CoNi-P@Ni).

Electric Double Layer Oriented Eutectic Additive Design toward Stable Zn Anodes with a High Depth of Discharge.

ZnSO-based electrolytes for aqueous zinc ion batteries fail to meet practical application metrics due to hydrogen evolution reaction (HER) and dendrite growth. In this work, a highly polarized eutectic additive, glycerophosphorylcholine (GPC) is rationally designed, to regulate the electric double layer (EDL) structure for stable Zn anodes with a high depth of discharge (DOD). On one hand, GPC molecules with abundant hydroxyl groups can precisely regulate the hydrogen bond network in EDL to suppress HER.

Measurement of the Centrality Dependence of the Dijet Yield in p+Pb Collisions at sqrt[s_{NN}]=8.16 TeV with the ATLAS Detector.

ATLAS measured the centrality dependence of the dijet yield using 165  nb^{-1} of p+Pb data collected at sqrt[s_{NN}]=8.16  TeV in 2016. The event centrality, which reflects the p+Pb impact parameter, is characterized by the total transverse energy registered in the Pb-going side of the forward calorimeter.

A gene-encoded aldehyde tag repurposed from RiPP cyclophane-forming pathway.

Gene-encoded aldehyde tag technology has been widely utilized in protein bioorthogonal chemistry and biotechnological application. Herein, we report utilization of the promiscuous rSAM cyclophane synthase SjiB involved in triceptide biosynthesis as a dedicated and highly efficient formylglycine synthase. The new aldehyde tag sequence in this system, YQSSI, is biosynthetically orthogonal to the known aldehyde tag (C/S)x(P/A)xR.

Local electronic structure engineering of vanadium-doped nickel phosphide nanosheet arrays for efficient hydrogen evolution.

Local electronic structure engineering is an effective approach for optimizing the catalytic performance of electrocatalysts. Herein, a dual-phase vanadium-doped nickel phosphide (NiVP) catalyst supported on nickel foam (NF) was synthesized via a successive hydrothermal and phosphorization process with interconnected nanosheet structures and homogeneous distributions. The catalyst's stable phase and strong adhesion to the substrate ensure good electrochemical stability.

Development of a Clinicopathological-Radiomics Model for Predicting Progression and Recurrence in Meningioma Patients.

Rationale And Objectives: Tumor progression and recurrence（P/R）after surgical resection are common in meningioma patients and can indicate poor prognosis. This study aimed to investigate the values of clinicopathological information and preoperative magnetic resonance imaging (MRI) radiomics in predicting P/R and progression-free survival (PFS) in meningioma patients.

Methods And Materials: A total of 169 patients with pathologically confirmed meningioma were included in this study, 54 of whom experienced P/R.

Noble metal-free bimetallic phosphide-decorated ZnCdS with efficient photocatalytic H evolution.

The rapid recombination of charge carriers in semiconductor-based photocatalysts results in a low photocatalytic activity. Co-catalysis is considered a promising strategy to improve the photocatalytic performance of semiconductors. In this study, a bimetallic phosphide was grown by a facile growth method.

Prediction of a planar BP monolayer with inherent metallicity and its potential as an anode material for Na and K-ion batteries: a first-principles study.

Borophene, the lightest two-dimensional material, exhibits exceptional storage capacity as an anode material for sodium-ion batteries (NIBs) and potassium-ion batteries (PIBs). However, the pronounced surface activity gives rise to strong interfacial bonding between borophene and the metal substrate it grows on. Incorporation of heterogeneous atoms capable of forming strong bonds with boron to increase borophene stability while preserving its intrinsic metallic conductivity and high theoretical capacity remains a great challenge.

Valley-dimensionality locking of superconductivity in cubic phosphides.

Two-dimensional superconductivity is primarily realized in atomically thin layers through extreme exfoliation, epitaxial growth, or interfacial gating. Apart from their technical challenges, these approaches lack sufficient control over the Fermiology of superconducting systems. Here, we offer a Fermiology-engineering approach, allowing us to desirably tune the coherence length of Cooper pairs and the dimensionality of superconducting states in arsenic phosphides AsP under hydrostatic pressure.

Metal-organic framework-mediated construction of confined ultrafine nickel phosphide immobilized in reduced graphene oxide with excellent cycle stability for asymmetric supercapacitors.

Transition metal phosphides (TMPs) with unique metalloid features have been promised great application potential in developing high-efficiency electrode materials for electrochemical energy storage. Nevertheless, sluggish ion transportation and poor cycling stability are the critical hurdles limiting their application prospects. Herein, we presented the metal-organic framework-mediated construction of ultrafine NiP immobilized in reduced graphene oxide (rGO).

Role of the gut microbiota and their metabolites in hemodialysis patients.

High serum phosphate levels in chronic kidney disease (CKD) are linked to adverse health outcomes, including cardiovascular disease, kidney disease progression, and all-cause mortality. This study is aimed to find out which microorganisms or microbial functions have a significant impact on higher calcium-phosphorus product (Ca x P) after they undergo hemodialysis (HD) treatment. samples from 30 healthy controls, 15 dialysis patients with controlled Ca xP (HD), and 16 dialysis patients with higher Ca xP (HDHCP) were collected to perform in 16S amplicon sequencing.

Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection.

Background: Aortic dissection (AD) is a fatal cardiovascular disorder without effective medications due to unclear pathogenic mechanisms. Bestrophin3 (Best3), the predominant isoform of bestrophin family in vessels, has emerged as critical for vascular pathological processes. However, the contribution of Best3 to vascular diseases remains elusive.

Optimized Solid Electrolyte Interphase and Solvation Structure of Potassium Ions in Carbonate Electrolytes for High-Performance Potassium Metal Batteries.

The introduction of electrolyte additives is one of the most potential strategies to improve the performance of potassium metal batteries (PMBs). However, designing an additive that can alter the K solvation shell and essentially inhibit K dendrite remains a challenge. Herein, the amyl-triphenyl-phosphonium bromide was introduced as an additive to build a stable solid electrolyte interphase layer.

Black Arsenic-Phosphorus Nanosheets for Highly Responsive Photodetection and Dual-Wavelength Ultrafast Pulse Generation at Telecommunication Bands.

Black arsenic-phosphorus (b-AsP), an alloy containing black phosphorus and arsenic in the form of b-AsP, has a broadly tunable band gap changing with the chemical ratios of As and P. Although mid-infrared photodetectors and mode-locked or Q-switched pulse lasers based on b-AsP (mostly b-AsP) are investigated, the potential of this family of materials for near-infrared photonic and optoelectronic applications at telecommunication bands is not fully explored. Here, we have verified a multifunctional fiber device based on b-AsP nanosheets for highly responsive photodetection and dual-wavelength ultrafast pulse generation at around 1550 nm.

PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.

Protein kinase-mediated phosphorylation plays a critical role in many biological processes. However, the identification of key regulatory kinases is still a great challenge. Here, we develop a trans-omics-based method, central kinase inference, to predict potentially key kinases by integrating quantitative transcriptomic and phosphoproteomic data.

Chitosan-driven biocompatible hydrogel based on water-soluble polypyrrole for stable human-machine interfaces.

Recently, wearable hydrogel sensors based on polypyrrole have shown considerable promise in the realms of human-machine interfaces. However, because of the water insolubility of pyrrole and polypyrrole, the preparation of polypyrrole conductive hydrogels with comprehensive properties by a simplified method remains a great challenge. Herein, the water-soluble polypyrrole was synthesized and the conformal CP conductive hydrogels were fabricated by the strategy of one-pot method of introducing chitosan and water-soluble polypyrrole into acrylamide matrix containing cucurbit[7]uril.