Publications by authors named "X-L Zhao"
Background: Although the information on the validation status of electronic sphygmomanometer (ES) devices in use in health care institutions and households is much more clinically relevant than that of ES models available on the market, it remains insufficient.
Methods: A national survey was conducted across all administrative regions of mainland China to assess the validation status of ESs. Fifty-eight cities were selected with stratification by municipality, provincial capital, and other cities, and health care institutions and households in each city were chosen by convenience to identify ES devices in use according to the study protocol.
Immunotherapeutics against triple-negative breast cancer (TNBC) hold great promise. In this work, we provide a combination therapy for simultaneous increasing tumor immunogenicity and down-regulating programmed cell death ligand 1 (PD-L1) to boost antitumor immunity in TNBC. We prepare bis (diethyldithiocarbamate)-copper/indocyanine green nanoparticles (CuET/ICG NPs) simply in aqueous with one-pot method.
View Article and Find Full Text PDFBackground And Purpose: DWI is crucial for detecting infarction stroke. However, its spatial resolution is often limited, hindering accurate lesion visualization. Our aim was to evaluate the image quality and diagnostic confidence of deep learning (DL)-based super-resolution reconstruction for brain DWI of infarction stroke.
View Article and Find Full Text PDFBackground: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.
Methods: Patients with ischemic stroke presenting 4.
Background: CDK4/6 inhibitors are highly valued, but the incidence of cardiovascular adverse events (CVAEs) associated with CDK4/6 inhibitors is not clear.
Objective: Our aim was therefore to assess the risk of developing CVAEs associated with CDK4/6 inhibitors, by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs), along with a pharmacovigilance study of the FDA Adverse Event Reporting System (FAERS) database.
Methods: Eligible CVAEs were extracted from the ClinicalTrials.
CD8 T cells exhibit remarkable phenotypic diversity in inflammation and cancer. However, a comprehensive understanding of their clonal landscape and dynamics remains elusive. Here we introduce scAtlasVAE, a deep-learning-based model for the integration of large-scale single-cell RNA sequencing data and cross-atlas comparisons.
View Article and Find Full Text PDFThe COVID-19 pandemic, exacerbated by persistent viral mutations, underscored the urgent need for diverse inhibitors targeting multiple viral proteins. In this study, we utilized covalent DNA-encoded libraries to discover innovative triazine-based covalent inhibitors for the 3-chymotrypsin-like protease (3CL, Nsp5) and the papain-like protease (PL) domains of Nsp3, as well as novel non-nucleoside covalent inhibitors for the nonstructural protein 12 (Nsp12, RdRp). Optimization through molecular docking and medicinal chemistry led to the development of , a nonpeptide 3CL inhibitor with an IC of 0.
View Article and Find Full Text PDFBackground: Reducing mortality among those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a critical challenge in clinic. The objective of this study was to analyze the effect of the coronavirus disease 2019 (COVID-19) vaccine on the prognosis of individuals infected with the Delta variant of SARS-CoV-2.
Methods: In a single-center, retrospective cohort study, all adult patients with COVID-19 from designated hospital in Xi'an, China, during the Delta outbreak from December 2021 to January 2022 were enrolled.
Article Synopsis
- Accurate treatment response assessment using serial CT scans is crucial for cancer clinical trials, but the current method (RECIST guideline) can be subjective and imprecise, especially for multifocal liver cancer lesions.
- The newly developed RECORD system utilizes deep learning to objectively evaluate treatment responses, segment liver tumors, and provide classifications based on tumor volume analysis, achieving high accuracy in assessments across multiple studies.
- RECORD outperforms traditional methods by correlating strongly with clinical evaluations and effectively stratifying patient risks, suggesting a need for future research to apply this technology to other types of cancer.
Article Synopsis
- - Intracranial neural electrodes offer valuable insights for research and treatment of neurological diseases but require invasive surgery, which can harm brain tissue and disrupt functions.
- - New endovascular neural devices present a less invasive alternative but currently lack the capability to capture single-unit activity in larger animals and humans, limiting their clinical use.
- - The ultraflexible implantable neural electrode (uFINE-I) demonstrates successful implantation in sheep, recording high-resolution neural activity with minimal tissue damage, paving the way for future applications in brain-machine interfaces and neurological treatments.
Article Synopsis
- - The study focuses on improving the inhaled delivery of mRNA using lipid nanoparticles (LNP), which face challenges like disintegration and aggregation during nebulization, hindering treatment effectiveness for lung diseases and mucosal vaccines.
- - A new strategy called charge-assisted stabilization (CAS) enhances LNP stability by creating electrostatic repulsions, leading to better mRNA delivery in animal models (mouse, dog, and pig).
- - The effective delivery of inhaled CAS-LNP triggers strong immune responses and shows potential as a vaccine against the SARS-CoV-2 Omicron variant, as well as for cancer treatment to reduce lung metastasis.
During shoulder arthroscopic surgery in the lateral decubitus position, effective and stable continuous traction is a basic requirement for the smooth progression of the surgery. Herein, we describe a safe, reliable, and cost-effective lateral decubitus traction assembly.
View Article and Find Full Text PDFIntroduction: Liver stiffness measurement is principal for staging liver fibrosis but not included in routine examinations. We investigated whether comparable diagnostic performance can be achieved by mining ultrasound images and developing a novel serum index (NSI).
Methods: Texture features were extracted from ultrasound images.
Background: Given the growing acknowledgment of the detrimental effects of excessive myocardial fibrosis on pathological remodeling after myocardial ischemia-reperfusion injury (I/R), targeting the modulation of myocardial fibrosis may offer protective and therapeutic advantages. However, effective clinical interventions and therapies that target myocardial fibrosis remain limited. As a promising chimeric antigen receptor (CAR) cell therapy, whether CAR macrophages (CAR-Ms) can be used to treat I/R remains unclear.
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- The text discusses the need for improved detection of vulnerable road users (VRUs) like pedestrians and cyclists in autonomous driving to enhance safety.
- It highlights the inadequacy of traditional classification methods due to the similarity between these two groups, prompting the development of a new algorithm based on the micro-Doppler effect.
- The proposed method uses advanced data processing techniques and a support vector machine for better classification accuracy, showing superior performance through various testing methods.
Background: Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results of a phase 2 trial suggested that ziresovir may have efficacy in the treatment of infants hospitalized with RSV infection.
Methods: In a phase 3, multicenter, double-blind, randomized, placebo-controlled trial conducted in China, we enrolled participants 1 to 24 months of age who were hospitalized with RSV infection.
Article Synopsis
- The BAD-study was a comprehensive analysis of branch atheromatous disease (BAD)-related strokes in 476 patients across 20 hospitals in China, focusing on demographic, clinical, and therapeutic aspects.
- The study found that the majority of participants were middle-aged and male, with a higher occurrence of strokes linked to the lenticulostriate artery; 86.5% of patients had good outcomes by 90 days, despite 14.7% experiencing early neurological deterioration.
- Key predictors of poor outcomes included higher stroke severity at admission and early deterioration, while extracranial artery stenosis was associated with better outcomes.
Article Synopsis
- The study evaluated the safety and effectiveness of administering the inactivated quadrivalent influenza vaccine (IIV4) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) together in adults aged 60 and older in China.
- Participants were split into two groups: one received both vaccines at the same time (C group) and the other received them separately (S group). Blood samples were tested for antibody levels after vaccination.
- Results showed that the immune response from the combined administration was comparable to the separate administration, with fewer adverse events reported in the C group, indicating that it is a safe option for older adults.
Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immunoglobulin and mucin domain containing-3 (Tim-3), a promising immune checkpoint target, is cleaved by ADAM10/17 to produce its soluble form (sTim-3) in humans, potentially becoming involved in anti-PD-1 resistance. Herein, serum sTim-3 upregulation was observed in non-small cell lung cancer (NSCLC) and various digestive tumors.
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- The study looked at how a liver disease called MASLD affects many other health problems for people in Europe.
- Researchers analyzed a lot of data to find connections between MASLD and 96 different diseases, like heart and metabolic issues.
- The findings will help doctors create better treatments for people with MASLD by understanding how it interacts with other health problems.
Background: Macrophages are key players in obesity-associated cardiovascular diseases, which are marked by inflammatory and immune alterations. However, the pathophysiological mechanisms underlying macrophage's role in obesity-induced cardiac inflammation are incompletely understood. Our study aimed to identify the key macrophage population involved in obesity-induced cardiac dysfunction and investigate the molecular mechanism that contributes to the inflammatory response.
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- The evolution of SARS-CoV-2 variants highlights the need for multivalent vaccines, leading to the development of SCTV01E, a tetravalent COVID-19 vaccine targeting variants Alpha, Beta, Delta, and Omicron BA.1.
- A double-blind placebo-controlled trial showed SCTV01E had a vaccine efficacy of 69.4% against COVID-19 seven days post-vaccination, with higher efficacy rates in preventing symptomatic and all infections at 14 days.
- The vaccine demonstrated a significant neutralizing antibody response against Omicron BA.5 and had mild reactogenicity, indicating its potential effectiveness against emerging SARS-CoV-2 variants.
Article Synopsis
- Therapeutic HPV vaccines are needed to induce strong cellular immunity and treat existing infections but face challenges, particularly with current delivery methods like electroporation (EP), which can cause pain and muscle damage.
- DNA-based HPV vaccines appear promising with good safety and efficacy, but EP's complexity and cost limit their clinical use.
- In preclinical tests, lipid nanoparticles (LNPs) significantly improved the immune response from DNA vaccines compared to EP, with SM-102 LNP M showing the best results, suggesting LNPs could offer a better delivery method.
Objectives: To establish normative values and identify potential factors influencing pancreatic iodine uptake using dual-energy CT (DECT).
Materials And Methods: This retrospective study included participants without pancreatic diseases undergoing DECT at two institutions with different platforms. Their protocols both included arterial phase (AP), portal venous phase (PP), and equilibrium phase (EP), defined as 35 s-40 s, 60 s-70 s, and 150 s-180 s after injection of contrast agent, respectively.