Safety and Efficacy of Remote Ischemic Conditioning in Patients With Intravenous Thrombolysis: The SERIC-IVT Trial.

Background: Approximately half of the patients with acute ischemic stroke who receive intravenous thrombolysis (IVT) do not achieve an excellent outcome. Remote ischemic conditioning (RIC) as a promising neuroprotective treatment may improve clinical outcomes in this population. This study aimed to assess the efficacy and safety of RIC in patients with IVT.

Real-Time Detection of Dynamic Restructuring in KNiFe F Perovskite Fluorides for Enhanced Water Oxidation.

Mechanistic understanding of how electrode-electrolyte interfaces evolve dynamically is crucial for advancing water-electrolysis technology, especially the restructuring of catalyst surface during complex electrocatalytic reactions. However, for perovskite fluorides, the mechanistic exploration for the influence of the dynamic restructuring on their chemical property and catalytic mechanism is unclear due to their poor conductivity that makes the definition of electrocatalyst structure difficult. Herein, for oxygen evolution reaction (OER), various operando characterizations are employed to investigate the structure-activity relationships of the KNiFe F@NF.

Non-metallic surface-modified X-Cu (X = F, Cl, Br) metal catalysts for all-pH hydrogen evolution reaction with high performance.

Producing hydrogen through water electrolysis represents a clean and sustainable solution that is crucial in addressing the energy crisis. Nonetheless, the slow process of water electrolysis leads to large different kinetics for hydrogen evolution reaction (HER) under different pH solutions. Here, we designed surface modified metallic X-Cu catalysts (X = F, Cl, Br) with different non-metallic elements on nickel foam (NF) using an electrochemical deposition method, which realizes high performance for all-pH range.

Serum GFAP and UCH-L1 Levels for the Assessment of the Absence of Hemorrhagic Transformation: A Multicenter Prospective Cohort Study.

Background: Currently, validated biomarkers for assessing hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) are lacking. We aimed to validate a test combining GFAP (glial fibrillary acidic protein) and UCH-L1 (ubiquitin C-terminal hydrolase-L1) to indicate the absence of HT after IVT.

Methods: We prospectively enrolled consecutive patients with stroke treated with IVT from 16 hospitals.

Regulation of Coordinating Anions around Single Co(II) Sites in a Covalent Organic Framework for Boosting CO Photoreduction.

While photocatalytic CO reduction has been intensively investigated, reports on the influence of anions coordinated to catalytic metal sites on CO photoreduction remain limited. Herein, different coordinated anions (F, Cl, OAc, and NO ) around single Co sites installed on bipyridine-based three-component covalent organic frameworks (COFs) were synthesized, affording TBD-COF-Co-X (X = F, Cl, OAc, and NO), for photocatalytic CO reduction. Notably, the presence of these coordinated anions on the Co sites significantly influences the photocatalytic performance, where TBD-COF-Co-F exhibits superior activity to its counterparts.

The Investigation on the Reactivity and the Formation of Halogen Bond Complexes for the Reactions of α-Nucleophiles XO (X = F, *Cl, Br, I) and CHCHCl.

Precise prediction of reactivity and accurately identifying the types of reaction complexes are prerequisites for delineating the microscopic mechanisms of ion-molecule reactions, which remain unclear for reactions involving α-nucleophilic reagents. Here, we investigate the potential energy surface of the multiatomic reactions XO (X = F, *Cl, Br, I) + CHCHCl to elucidate the optimal descriptors for reaction reactivity and the origin of halogen bond/hydrogen bond compounds. Through analyzing the orbital composition and the relationship of energy barriers with the proton affinity and nucleophilic index, the local nucleophilic index is ultimately determined to be the optimal descriptor for predicting the reactivity of the reactions with α-nucleophilic reagents.

Dual ligand-enabled iron and halogen-containing carboxylate-based photocatalysis for chloro/fluoro-polyhaloalkylation of alkenes.

Herein, we demonstrate a practical dual ligand-enabled iron photocatalysis paradigm-converting all kinds of halogen-containing carboxylates (C X COO, X: F, Cl, Br) into C X radicals for the valuable chloro/fluoro-polyhaloalkylation of non-activated alkenes with easily available trichloroacetonitrile/Selectfluor as the electrophilic halogenation reagent. The modular assembly of the effective iron and C X COO-based light-harvesting species using the two ligands-OMe/CF-substituted bipyridine and acetonitrile/trichloroacetonitrile is evidenced by detailed mechanistic studies. The late-stage modification, low loading amount of iron (TON: 257) and feasible gram-scale synthesis show the utility of this protocol.

Design, Bioactivity, and Action Mechanism of Pyridinecarbaldehyde Phenylhydrazone Derivatives with Broad-Spectrum Antifungal Activity.

Replacing old pesticides with new pesticide varieties has been the main means to solve pesticide resistance. Therefore, it is necessary to research and develop new antifungal agents for plant protection. In this study, a series of pyridinecarbaldehyde phenylhydrazone derivatives were designed and evaluated for their inhibition activity on plant pathogenic fungi to search for novel fungicide candidates.

Synergistic Effect of Defects Passivation and Energy Level Alignment Realizing P3HT-Based High-Efficiency CsPbI Perovskite Solar Cells.

Poly (3-hexylthiophene) (P3HT) is one of the most efficient hole transport layers (HTLs) in perovskite solar cells (PSCs). However, surface and boundary defects in CsPbI, and energy level mismatch between CsPbI and P3HT lead to a low power conversion efficiency (PCE) in P3HT-based CsPbI PSCs. Here, a synergistic strategy with anti-solvent (sec-pentyl alcohol, 2-PA) and passivators (LiX, X = F, Cl, Br, I) is developed to promote the photovoltaic performance of P3HT-based CsPbI PSCs.

Sacrificial Additive C-Assisted Catholyte Buffer Layer for LiAlTi(PO)-Based All-Solid-State High-Voltage Batteries.

All-solid-state batteries with oxide electrolytes and high-nickel layered oxide cathodes (LiNiCoMnO and LiNiCoAlO, + + = 1, ≥ 60%) have received widespread attention owing to their high energy density and high safety. However, they generally suffer from interfacial structural instability when coupled with solid-state electrolytes, which strongly diminishes the longevity of the battery. In this work, we propose adding a sacrificial additive C to the catholyte buffer layer between LiAlTi(PO) (LATP) and LiNiCoMnO (NCM811) to enhance the electrochemical stability under high-voltage operating conditions.

Tailoring local electron density and molecular oxygen activation behavior via potassium/halogen co-tuned graphitic carbon nitride for enhanced photocatalytic activity.

Graphite carbon nitride (g-CN) is a promising photocatalyst,but its inadequate reactive sites, weak visible light responsiveness, and sluggish separation of photogenerated carriers hamperthe improvement of photodegradation efficiency. In this work, potassium (K) and halogen atoms co-modified g-CN photocatalysts (CN-KX, X = F, Cl, Br, I) were constructed to adjust the electrical and band structure for enhanced generation of reactive oxygen species. Through an integration of theoretical calculation and experimental exploration, the doping sites of halogen atoms as well as the evolution of crystal, band, and electronic structures were investigated.

Exploring habitats-based spatial distributions: improving predictions of lymphovascular invasion in invasive breast cancer.

Rationale And Objectives: Accurate assessment of lymphovascular invasion (LVI) in invasive breast cancer (IBC) plays a pivotal role in tailoring personalized treatment plans. This study aimed to investigate habitats-based spatial distributions to quantitatively measure tumor heterogeneity on multiparametric magnetic resonance imaging (MRI) scans and assess their predictive capability for LVI in patients with IBC.

Materials And Methods: In this retrospective cohort study, we consecutively enrolled 241 women diagnosed with IBC between July 2020 and July 2023 and who had 1.

MRI-Based Prediction of Clinical Improvement after Ventricular Shunt Placement for Normal Pressure Hydrocephalus: Development and Evaluation of an Integrated Multisequence Machine Learning Algorithm.

Background And Purpose: Symptoms of normal pressure hydrocephalus (NPH) are sometimes refractory to shunt placement, with limited ability to predict improvement for individual patients. We evaluated an MRI-based artificial intelligence method to predict postshunt NPH symptom improvement.

Materials And Methods: Patients with NPH who underwent MRI before shunt placement at a single center (2014-2021) were identified.

Concentration effects on the local structures and electronic properties of ErBaYF: a first-principles study.

Erdoped barium yttrium fluoride (BaYF) crystal has gained long-term attention due to its great potential in laser and medical device applications. However, the local structures of Erdoped BaYFsystem (Er:BYF) remain uncertain, and the effect of doping concentration on structures and properties is unknown. Therefore, in this study, the first-principles study of the structural evolution of ErBaYF(= 0.

High-Voltage NaNiMgMnOF Cathode Improved by One-Step In Situ MgF Doping with Superior Low-Temperature Performance and Extra-Stable Air Stability.

P2-NaMnO has garnered significant attention due to its favorable Na conductivity and structural stability for large-scale energy storage fields. However, achieving a balance between high energy density and extended cycling stability remains a challenge due to the Jahn-Teller distortion of Mn and anionic activity above 4.1 V.

Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virus.

Unlabelled: African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and infection. By engineering CRISPR-Cas systems to target nine specific loci within the ASFV genome, we observed a substantial reduction in viral replication .

Impact of Off-Hour Admission on In-Hospital Outcomes for Patients With Stroke Receiving Reperfusion Therapy in China.

Background: The structure and staffing of hospitals greatly impact patient outcomes, with frequent changes occurring during nights and weekends. This retrospective cohort study assessed the impact of admission timing on in-hospital management and outcomes for patients with stroke receiving reperfusion therapy in China using data from a nationwide registry.

Methods: Data from patients receiving reperfusion therapy were extracted from the Chinese Stroke Center Alliance.

Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus.

Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially in infants and the elderly. The identification and structural resolution of the potent neutralizing epitopes on RSV fusion (F) protein enable an "epitope-focused" vaccine design. However, the display of RSV F epitope II on the surface of the widely-used human hepatitis B virus core antigen (HBcAg) has failed to induce neutralizing antibody response in mice.

Remote Ischemic Conditioning With Medical Management or Reperfusion Therapy for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Background And Objectives: Remote ischemic conditioning (RIC) is a low-cost, accessible, and noninvasive neuroprotective treatment strategy, but its efficacy and safety in acute ischemic stroke are controversial. With the publication of several randomized controlled trials (RCTs) and the recent results of the RESIST trial, it may be possible to identify the patient population that may (or may not) benefit from RIC. This systematic review and meta-analysis aims to evaluate the effectiveness and safety of RIC in patients with ischemic stroke receiving different treatments by pooling data of all randomized controlled studies to date.

Two-Dimensional Spin-Crossover Molecular Solid Solutions with Tunable Transition Temperatures across 90 K.

Spin-crossover (SCO) materials exhibit remarkable potential as bistable switches in molecular devices. However, the spin transition temperatures () of known compounds are unable to cover the entire ambient temperature spectrum, largely limiting their practical utility. This study reports an exemplary two-dimensional SCO solid solution system, = 5--2-hydroxybenzylidene-hydrazinecarbothioamide, = F or Cl, = 0 to 1), in which the adjacent layers are adhered via hydrogen bonding.