Prognostic significance of stress dynamic myocardial CT perfusion: comparison with CT-FFR and CT angiography stenosis-the multicenter VALIDITY trial.

Objectives: This study aimed to investigate the prognostic significance of stress dynamic myocardial CT perfusion imaging (CTP) and determine whether it has incremental advantages over coronary computed tomography angiography (CTA)-derived parameters.

Methods: This prospective multicenter study included patients with suspected coronary artery disease who had undergone coronary CTA and CTP and were followed for 6 years. The endpoint was time-to-first major adverse cardiovascular event (MACE).

Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank.

Whole-genome sequencing (WGS), whole-exome sequencing (WES) and array genotyping with imputation (IMP) are common strategies for assessing genetic variation and its association with medically relevant phenotypes. To date, there has been no systematic empirical assessment of the yield of these approaches when applied to hundreds of thousands of samples to enable the discovery of complex trait genetic signals. Using data for 100 complex traits from 149,195 individuals in the UK Biobank, we systematically compare the relative yield of these strategies in genetic association studies.

Phase 1 Open-Label Study of Omigapil in Patients With LAMA2- or COL6-Related Dystrophy.

Background And Objectives: Omigapil is a small molecule which inhibits the GAPDH-Siah1-mediated apoptosis pathway. Apoptosis is a pathomechanism underlying the congenital muscular dystrophy subtypes LAMA2-related dystrophy (LAMA2-RD) and COL6-related dystrophy (COL6-RD). Studies of omigapil in the (dy/dy) LAMA2-RD mouse model demonstrated improved survival, and studies in the (dy/dy) LAMA2-RD mouse model and the (Col6a1) COL6-RD mouse model demonstrated decreased apoptosis.

Rational Design of NiCo-borate/GO Heterojunction as a High-Performance Supercapacitor Electrode.

The bottleneck in the preparation of supercapacitors is how to develop high-energy and high-power-density devices by using appropriate materials. Herein, a novel NiCo-B/GO heterostructure material was synthesized through a simple ultrasonic and precipitation method. The prepared NiCo-B/GO heterostructure exhibits significant improvements in supercapacitor performance than NiCo-B.

Prediction of potential hard sodium carbaboride compounds assuming sp-bonded covalent clathrates.

Boron-carbon clathrates have attracted great attention due to their unique sp-bonded structure and excellent electronic properties. Here, by performing first-principles calculations, we predicted six stoichiometric Na-B-C clathrates (NaBC, NaBC, NaBC, NaBC, NaBC, and NaBC) based on Na-doped boron-carbon clathrates. As a result, NaBC, NaBC, and NaBC were found to become energetically favorable.

XPu(CO) (X = B, Al, Ga; = 2 to 4): π Back-Bonding in Heterodinuclear Plutonium Boron Group Compounds with an End-On Carbonyl Ligand.

The bonding situation and the oxidation state of plutonium in heterodinuclear plutonium boron group carbonyl compounds XPu(CO) (X = B, Al, Ga; = 2 to 4) were investigated by systematically searching their ground-state geometrical structures and by analyzing their electronic structures. We found that the series of XPu(CO) compounds show various interesting structures with an increment in as well as a changeover from X = B to Ga. The first ethylene dione (OCCO) compounds of plutonium are found in AlPu(CO) ( = 2, 3).

Measurements of the associated production of a W boson and a charm quark in proton-proton collisions at .

Measurements of the associated production of a W boson and a charm ( ) quark in proton-proton collisions at a centre-of-mass energy of 8 are reported. The analysis uses a data sample corresponding to a total integrated luminosity of 19.7 collected by the CMS detector at the LHC.

Structure/Interface Coupling Effect for High-Voltage LiCoO Cathodes.

LiCoO (LCO) is widely applied in today's rechargeable battery markets for consumer electronic devices. However, LCO operations at high voltage are hindered by accelerated structure degradation and electrode/electrolyte interface decomposition. To overcome these challenges, co-modified LCO (defined as CB-Mg-LCO) that couples pillar structures with interface shielding are successfully synthesized for achieving high-energy-density and structurally stable cathode material.

GABAergic neuronal IL-4R mediates T cell effect on memory.

Mechanisms governing how immune cells and their derived molecules impact homeostatic brain function are still poorly understood. Here, we elucidate neuronal mechanisms underlying T cell effects on synaptic function and episodic memory. Depletion of CD4 T cells led to memory deficits and impaired long-term potentiation.

Reaction Mechanism of ZrB-ZrC Formation in Ni-Zr-BC System Analyzed by Differential Scanning Calorimetry.

The reaction mechanism of ZrB-ZrC formation in a 30% Ni-Zr-BC system under argon was revealed by using differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results indicated that the reaction mechanism in the Ni-Zr-BC system was complex. Initially, NiZr and NiB intermetallics were formed via solid-state diffusion reactions between Ni, BC and Zr.

Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells.

Mercuric chloride (HgCl) is a serious environmental toxicant. So far, the toxicity mechanism of HgCl in chicken embryonic kidney (CEK) cells is not still fully understood. In this study, the possible molecular mechanisms of HgCl on apoptosis of CEK cells were investigated.

Automatic Machine Learning to Differentiate Pediatric Posterior Fossa Tumors on Routine MR Imaging.

Background And Purpose: Differentiating the types of pediatric posterior fossa tumors on routine imaging may help in preoperative evaluation and guide surgical resection planning. However, qualitative radiologic MR imaging review has limited performance. This study aimed to compare different machine learning approaches to classify pediatric posterior fossa tumors on routine MR imaging.

Physical Properties of XN (X = B, Al, Ga, In) in the - phase: First-Principles Calculations.

Three direct semiconductor materials and one indirect semiconductor material, -3 XN (X = B, Al, Ga, In), are investigated in our work, employing density functional theory (DFT), where the structural properties, stability, elastic properties, elastic anisotropy properties and electronic properties are included. The shear modulus and bulk modulus of -3 BN are 290 GPa and 244 GPa, respectively, which are slightly less than the values of and for c-BN and BN, while they are larger than those of C in the 4/ phase. The shear modulus of -3 BN is the greatest, and the shear modulus of C in the 4/ phase is the smallest.

Predictive role of heterozygous p.R4810K of in the phenotype of Chinese moyamoya disease.

Objective: Precise genetic analyses were conducted with ring finger protein 213 () in relation to a particular clinical phenotype in Chinese patients with moyamoya disease (MMD) to determine whether heterozygosity is responsible for the early-onset and severe form of this disease.

Methods: A case-control study for p.R4810K involving 1,385 Chinese patients with MMD and 2,903 normal control participants was performed.

Measurement of the Absolute Branching Fraction of the Inclusive Decay Λ_{c}^{+}→Λ+X.

Based on an e^{+}e^{-} collision data sample corresponding to an integrated luminosity of 567  pb^{-1} taken at the center-of-mass energy of sqrt[s]=4.6  GeV with the BESIII detector, we measure the absolute branching fraction of the inclusive decay Λ_{c}^{+}→Λ+X to be B(Λ_{c}^{+}→Λ+X)=(38.2_{-2.

Measurement of associated Z + charm production in proton-proton collisions at .

A study of the associated production of a boson and a charm quark jet ( ), and a comparison to production with a quark jet ( ), in collisions at a centre-of-mass energy of 8 are presented. The analysis uses a data sample corresponding to an integrated luminosity of 19.7 , collected with the CMS detector at the CERN LHC.

Measurement of the cross section in pp collisions at and validation of lepton analysis techniques.

A measurement is presented of the cross section in collisions at , using data recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of . The product of the inclusive cross section and branching fraction is measured to be , in agreement with the standard model expectation, computed at next-to-next-to-leading order accuracy in perturbative quantum chromodynamics. The measurement is used to validate new analysis techniques relevant for future measurements of lepton production.

Search for Higgs boson pair production in the channel using collision data recorded at TeV with the ATLAS detector.

Searches for non-resonant and resonant Higgs boson pair production are performed in the channel with the final state of using 36.1  of proton-proton collision data recorded at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. No significant deviation from the Standard Model prediction is observed.

Controlled defect creation and removal in graphene and MoS monolayers.

It is known that defects strongly influence the properties of two-dimensional (2D) materials. The controlled creation and removal of defects can be utilized to tailor the optical and electronic responses of these 2D materials for optoelectronic and nanoelectronic applications. In this study, we developed an efficient approach to reversibly control the defect states in mechanically exfoliated graphene and molybdenum disulfide (MoS) monolayers.