GDC: Integration of Multi-Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss.

Effective research and clinical application in audiology and hearing loss (HL) require the integration of diverse data, yet the absence of a dedicated database impedes understanding and insight extraction in HL. To address this, the Genetic Deafness Commons (GDC) is developed by consolidating extensive genetic and genomic data from 51 public databases and the Chinese Deafness Genetics Consortium. This repository comprises 5 983 613 variants across 201 HL genes, revealing the genetic landscape of HL and identifying six novel mutational hotspots within the DNA-binding domains of transcription factors.

A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.

The dynamic interaction between central respiratory chemoreceptors and the respiratory central pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm and pattern, yet its circuit-level organization remains poorly characterized. Here, the functional connectivity between two key medullary hubs: the nucleus tractus solitarius (NTS) and the preBötzinger complex (preBötC) are systematically investigated. These findings delineate a medullary network primarily comprising Phox2b-expressing NTS neurons (NTS), GABAergic NTS neurons (NTS), and somatostatin (SST)-expressing preBötC neurons (preBötC).

Biomineralization-Inspired Membranization Toward Structural Enhancement of Coacervate Community.

The design and assembly of protocell models that can mimic the features and functions of life present a significant research challenge with the potential for far-reaching impact. Inspired by the natural phenomenon of microbe-induced mineralization, a way is developed to induce the spontaneous formation of mineralized membrane on the surface of coacervate droplets utilizing Fe ions. In particular, the effect of Fe ions on the microstructure of droplets at the molecular level is dissected by combining theoretical and experimental approaches.

ZEB1 promotes the immune escape of ovarian cancer through the MCSF-CCL18 axis.

This study aimed to determine the molecular mechanisms underlying immune escape in ovarian cancer. Samples of ovarian cancer were used to explore the regulatory pathways involved in the malignant phenotype. Tumor cell models with different levels of factor expression were constructed via transfection, and their regulation was determined through investigation of protein expressions.

Global output of clinical application research on artificial intelligence in the past decade: a scientometric study and science mapping.

Background: Artificial intelligence (AI) has shown immense potential in the field of medicine, but its actual effectiveness and safety still need to be validated through clinical trials. Currently, the research themes, methodologies, and development trends of AI-related clinical trials remain unclear, and further exploration of these studies will be crucial for uncovering AI's practical application potential and promoting its broader adoption in clinical settings.

Objective: To analyze the current status, hotspots, and trends of published clinical research on AI applications.