Personalized Nanovaccine Based on STING-Activating Nanocarrier for Robust Cancer Immunotherapy.

Tumor-specific T cells play a vital role in potent antitumor immunity. However, their efficacy is severely affected by the spatiotemporal orchestration of antigen-presentation as well as the innate immune response in dendritic cells (DCs). Herein, we develop a minimalist nanovaccine that exploits a dual immunofunctional polymeric nanoplatform (DIPNP) to encapsulate ovalbumin (OVA) via electrostatic interaction when the nanocarrier serves as both STING agonist and immune adjuvant in DCs.

Vertical migration characteristics of polychlorinated biphenyls (PCBs) in estuarine and coastal zones under complex environmental conditions.

As a transitional zone where rivers meet the sea, estuaries are influenced by river transport and ocean tides, resulting in complex variations in parameters such as organic matter content, pH, and sediment salinity. This paper primarily explores the vertical migration patterns of polychlorinated biphenyls (PCBs) under complex conditions, focusing on the soil sediments in the Dagu River estuary area. We designed an indoor soil column leaching experiment to investigate how soil organic matter content, pH, and salinity affect the vertical migration of PCBs in soil.

Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.

Genome-wide association studies (GWASs) have reported multiple risk loci for schizophrenia (SCZ). However, the majority of the associations were from populations of European ancestry. Here we conducted a large-scale GWAS in Eastern Asian populations (29,519 cases and 44,392 controls) and identified ten Eastern Asian-specific risk loci, two of which have not been previously reported.

MiR8523 negatively regulates the immunity of Plutella xylostella against entomopathogenic fungus Isaria cicadae by targeting PxSpz5.

The diamondback moth, Plutella xylostella is a notorious pest and has developed serious resistance to insecticides. Entomopathogenic fungi (EPF) have been developed as eco-friendly alternatives to insecticides. Insects rely on their immunity to defend against fungi.

Double step screening using endogenous marker improves relative gene targeting efficiency in Arabidopsis.

Gene targeting (GT) is a powerful tool for manipulating endogenous genomic sequences as intended. However, its efficiency is rather low, especially in seed plants. Numerous attempts have been made to improve the efficiency of GT via the CRISPR/Cas systems in plants, but these have not been sufficiently effective to be used routinely by everyone.