Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers.

Objective: Esophageal cancer (EC) ranks eighth among cancers in cancer-related deaths globally, and ~44% of new cases occur in China. We sought to describe the clinical characteristics and treatment landscape of EC in China before the approval of immunotherapy in 2020.

Methods: CHANNEL was a large, retrospective study using patient-level data from 14 hospitals/cancer centers across China, including adults initiating therapy for newly diagnosed EC (January to December 2018).

Effects of dietary Lactococcus lactis Z-2 on growth, host health and resistance to Aeromonas hydrophila in juvenile common carp (Cyprinus carpio L.).

Background: Lactococcus lactis Z-2 was previously isolated from common carp intestine. In order to investigate the effects of optimal dose of L. lactis Z-2 on growth, host health and disease resistance to Aeromonas hydrophila in common carp, five experimental diets, including without (CK and CK+ groups) or with 5 × 10 (group A), 5 × 10 (group B) and 5 × 10 CFU g (group C) L.

Diagnostic value of lung function tests in long COVID: analysis of positive bronchial provocation test outcomes.

Background: Long COVID patients are prone to bronchial hyperresponsiveness and respiratory symptoms like coughing and breathing difficulties, often with positive bronchial provocation test (BPT) results.

Objective: This study aims to evaluate the diagnostic value of various lung function tests in patients with long-term COVID-19, explicitly focusing on positive BPT outcomes.

Methods: Our study analyzed the BPT outcomes and various pulmonary function parameters of all 9,406 COVID-19 patients who met the inclusion criteria and visited our hospital between February 24, 2022, and April 28, 2024.

AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities.

Currently, the most common approach for manufacturing GMP-grade adeno-associated virus (AAV) vectors involves transiently transfecting mammalian cells with three plasmids that carry the essential components for production. The requirement for all three plasmids to be transfected into a single cell and the necessity for high quantities of input plasmid DNA, limits AAV production efficiency, introduces variability between production batches, and increases time and labor costs. Here, we developed an all-in-one, single-plasmid AAV production system, called AAVone.

The quantum anomalous Hall effect in two-dimensional hexagonal monolayers studied by first-principles calculations.

The quantum anomalous Hall effect (QAHE) demonstrates the potential for achieving quantized Hall resistance without the need for an external magnetic field, making it highly promising for reducing energy loss in electronic devices. Its realization and research rely heavily on precise first-principles calculations, which are essential for analyzing the electronic structures and topological properties of novel two-dimensional (2D) materials. This review article explores the theoretical progress of QAHE in 2D hexagonal monolayers with strong spin-orbit coupling and internal magnetic ordering.