This study employed the methods of serum chemistry, in vivo drug distribution analysis, and network pharmacology to investigate the potential therapeutic effects of Bufei Pills on respiratory disorders and decipher the underlying mechanisms. For the in vivo distribution study, rats were administrated with Bufei Pills, and the absorbed components were analyzed by HPLC-Q-TOF-MS/MS. The results showed that 56 components were present in the rat serum, including neocyclomorusin, asterinin A, neoisostegane, goimisin R, and frehmaglutoside H.
View Article and Find Full Text PDFShort-chain fatty acid ethyl esters (SFAEEs) are critical aroma compounds in Baijiu, and their wider concentration range can lead to differences in the quality grade of Baijiu. Efficiently designing an SFAEEs adsorbent before instrument analysis remains challenging. In this work, nine functionalized covalent organic frameworks (COFs) with different postmodification groups were designed for targeting SFAEEs.
View Article and Find Full Text PDFIndoleamine 2,3-dioxygenase 1 (IDO1) plays an anti-inflammatory role in autoimmune disease. However, its specific function in ankylosing spondylitis (AS) remain unclear. This study aimed to investigate the potential role of IDO1 in AS.
View Article and Find Full Text PDFA covalent organic framework (COF) based on imine was synthesized using 2,5-dihexoxyterephthalaldehyde (DHT) and 1,3,5-tris(4-aminophenyl) benzene (TAPB) as starting materials. The TAPB-DHT-COF exhibited satisfactory chemical stability, making it a promising adsorbing material for stir bar sorptive extraction (SBSE) of four estrogens, including estrone (E1), β-estradiol (E2), hexestrol (HES), and mestranol (MeEE2), in ambient water samples. The extracted analytes were subsequently analyzed using a high-performance liquid chromatography-diode array detector (HPLC-DAD).
View Article and Find Full Text PDFHardness constitutes one of the primary performance indices of bread. However, there is scarce literature regarding the study of the mechanisms of increased hardness in different breads. In this paper, the hardness and retrogradation rates of five popular brands of bread (DaliGarden, Mankattan, MianLunSi, TOLY, and ZhengMao) in China during storage at room temperature were determined, and the mechanism of increased hardness was revealed by the results in terms of Fourier transform infrared spectroscopy (FTIR), disulfide bonds, C solid-state nuclear magnetic resonance (NMR), X-ray diffraction, and differential scanning calorimetry (DSC).
View Article and Find Full Text PDF