Ginkgo Diterpene Lactone Meglumine for Functional Recovery in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Ethnopharmacological Relevance: The clinical efficacy of ginkgo diterpene lactone meglumine (GDLM), a Chinese patent medicine, in acute ischemic stroke (AIS) has garnered attention. However, the impact of GDLM on functional recovery in AIS patients has not been systematically reviewed or meta-analyzed.

Aim Of The Study: To evaluate the functional outcomes of GDLM in AIS patients.

Proteomics analysis reveals the antagonistic interaction between high CO and warming in the adaptation of the marine diatom Thalassiosira weissflogii in future oceans.

While it is known that warming and rising CO level might interactively affect the long-term adaptation of marine diatoms, the molecular and physiological mechanisms underlying these interactions in the marine diatom Thalassiosira weissflogii on an evolutionary scale remain largely unexplored. In this study, we investigated the changes in metabolic pathways and physiological responses of T. weissflogii under long-term ocean acidification and/or warming conditions (∼3.

A mitochondria-targeted nanozyme with enhanced antioxidant activity to prevent acute liver injury by remodeling mitochondria respiratory chain.

Developing nanomedicines with enhanced activity to scavenge reactive oxygen species (ROS) has emerged as a promising strategy for addressing ROS-associated diseases, such as drug-induced liver injury. However, designing nanozymes that not only remove ROS but also accelerate the repair of damaged liver cells remains challenging. Here, a two-pronged black phosphorus/Ceria nanozyme with mitochondria-targeting ability (TBP@CeO) is designed.

Competitive Effect of Surface Hydrophobicity-Hydrophilicity and the Number of Accessible Protons on Water-Assisted Proton Conductivity in Metal-Organic Frameworks: Dielectric σ-Relaxation Triggered by Disordered Guest Ionic Migration and Its Mechanism.

The rapid upsurge of metal-organic frameworks (MOFs) has sparked profound interest in their potential as proton conductors for proton exchange membrane fuel cells. However, proton-conducting behaviors of hydrophobic MOFs remain poorly understood compared with their hydrophilic counterparts, largely due to the absence of a microscopic phase separation structure akin to that found in Nafion membranes. Herein, we demonstrate a strategy for regulating the structures and proton conductivities of MOFs by separately incorporating hydrophobic -C(CF)- group alongside hydrophilic -O- and -SO- groups into organic ligands as linkers.

Measurement of Λ_{b}^{0}, Λ_{c}^{+}, and Λ Decay Parameters Using Λ_{b}^{0}→Λ_{c}^{+}h^{-} Decays.

A comprehensive study of the angular distributions in the bottom-baryon decays Λ_{b}^{0}→Λ_{c}^{+}h^{-}(h=π,K), followed by Λ_{c}^{+}→Λh^{+} with Λ→pπ^{-} or Λ_{c}^{+}→pK_{S}^{0} decays, is performed using a data sample of proton-proton collisions corresponding to an integrated luminosity of 9  fb^{-1} collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV. The decay parameters and the associated charge-parity (CP) asymmetries are measured, with no significant CP violation observed. For the first time, the Λ_{b}^{0}→Λ_{c}^{+}h^{-} decay parameters are measured.