Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy.

The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the gut microbiome a new potential therapeutic focus. This commentary examines the recent publication in . The article explores the association between T2DM and gut microbiota, with a focus on the pathophysiological changes related to dysbiosis.

Miniaturized fiber optic accelerometer incorporating liquid metal as the proof mass.

The inertial element of a solid block is commonly used as the proof mass in traditional accelerometers. However, it is challenging to accommodate both the high-density solid-state proof mass and the highly elastic component simultaneously in a miniature sensor, which makes it difficult for the sensors to maintain comparable sensing performance at a miniaturized size. Here, a novel, to the best of our knowledge, liquid metal-based fiber optic accelerometer (LMFOA) is proposed for the first time to meet this requirement.

Ultraviolet-Shielded Transparent Wood with Improved Interface for Insulating Windows.

Recently, transparent wood (TW) has been considered for many energy-efficient building products, such as windows and decorations. However, the existing TW still faces issues with size and thickness, as well as problems with functional fillers affecting the optical and mechanical properties of TW, which limits its wide application in the window products. In this study, a wood composite material (WCM) with good optical, mechanical, and thermal insulation and UV-shielding properties was prepared by using delignified wood (DW), methyl methacrylate (MMA), and 4-vinylphenylboric acid (VPBA).

Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts.

cis-regulatory elements (CREs) control gene transcription dynamics across cell types and in response to the environment. In asthma, multiple immune cell types play an important role in the inflammatory process. Genetic variants in CREs can also affect gene expression response dynamics and contribute to asthma risk.

Exploring gut microbiota as a novel therapeutic target in Crohn's disease: Insights and emerging strategies.

Extensive research has investigated the etiology of Crohn's disease (CD), encompassing genetic predisposition, lifestyle factors, and environmental triggers. Recently, the gut microbiome, recognized as the human body's second-largest gene pool, has garnered significant attention for its crucial role in the pathogenesis of CD. This paper investigates the mechanisms underlying CD, focusing on the role of 'creeping fat' in disease progression and exploring emerging therapeutic strategies, including fecal microbiota transplantation, enteral nutrition, and therapeutic diets.