Combining SKY92 gene expression profiling and FISH (according to R2-ISS) defines ultra-high-risk Multiple Myeloma.

The definition of high-risk (HR) multiple myeloma (MM) is still a matter of debate. We prospectively evaluated the HR detection using FISH in combination with SKY92 gene expression profiling in 258 MM patients (newly diagnosed [ND] MM:  = 109; relapsed/refractory [RR] MM:  = 149). HR SKY92 was significantly enriched in RRMM (57/121, 47.

Safety and efficacy of catheter ablation in atrial fibrillation patients with heart failure with preserved ejection fraction.

Purpose: Catheter ablation (CA) for atrial fibrillation (AF) in heart failure patients with preserved ejection fraction (HFPEF) has shown promising results in reducing mortality and improving heart function. However, previous studies have been limited by a lack of control groups and significant heterogeneity in their methodologies.

Hypothesis: CA for AF in HFPEF patients may not increase the complications and had similarly the rate of freedom from AF vs.

Effects of MeCP2 on chronic seizures and cognitive function in mice with temporal lobe epilepsy.

Mutations in methyl CpG binding protein 2 (MeCP2) are linked to Rett syndrome, in which epilepsy is one of the most well-described disorders. However, little is known about the specific role of MeCP2 during epileptogenesis. Our previous study has demonstrated that MeCP2 has a unique control on the development of mossy fiber sprouting (MFS) in the epileptic hippocampus.

Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer.

Backgrounds: Collagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. This has made COL1A1 a focal point in cancer biology research. However, studies investigating the relationship between COL1A1 expression levels and clinical characteristics of ovarian cancer (OC) remain limited.

Catalytic ozonation of dimethyl phthalate by Ti-MCM-41 in water.

A Ti-MCM-41 mesoporous molecular sieve catalyst was prepared by a hydrothermal method. Nitrogen adsorption desorption, XRD, TEM and SEM characterization results showed that the catalyst had a large specific surface area, a regular hexagonal pore structure, and titanium doping was uniformly dispersed in MCM-41 molecular sieves. The amount of titanium doping, reaction temperature, and the initial solution pH had important effects on the catalytic ozonation of dimethyl phthalate (DMP) by Ti-MCM-41.