Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating GG.

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With the growing knowledge about the gut-bone axis, the therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. Although GG (LGG) is widely reported to positively regulate bone metabolism by restoring the dysbiotic microbiome, oral administration is associated with sensitivity to gastric fluid and low bioavailability.

Unveiling the effect of social networks on farmers' diversified energy-saving behaviors in the Tibetan plateau region of China.

An improved comprehension of the factors that influence farmers' diversified energy-saving behaviors makes significant sense for enacting potent energy policies and curbing rural energy consumption. This paper investigated the effect of social networks on diversified energy-saving behaviors adopted by farmers in the Tibetan Plateau region of China, by establishing a generalized Poisson regression model. A total of 480 farmers were randomly interviewed.

Biomarkers.

Background: The development of reliable blood biomarkers for neurodegenerative diseases (NDDs) has been hindered by the lack of tools with sufficient sensitivity to detect low concentrations of brain-derived proteins in plasma or serum in a highly multiplexed manner. NULISA™ (NUcleic acid-Linked Immuno-Sandwich Assay) has emerged as a promising solution, with attomolar sensitivity and capable of high multiplexing in a fully automated system. In this study, we introduce NULISA CNS Disease Panel 120, a 120-plex NULISAseq assay for profiling key hallmarks of NDDs in both blood and cerebrospinal fluid (CSF).

Public Health.

Background: Depression is common in the elderly, which is regarded as is an important risk factor for mild cognitive impairment (MCI), and social participation has been proved to be effective in improving the mental health of the aged, while the relationship and acting path among depression, social participation and the occurrence of MCI are still unclear.

Method: This study included 190 older adults with MCI and 190 matched older adults without cognitive impairment. All participants were asked to complete Montreal Cognitive Assessment (MoCA), the Participation and Autonomy Questionnaire (IPA), the Physical Activity Scale for the Elderly (PASE) and the Short Form Geriatric Depression Scale (GDS-15).

Developing Topics.

Background: The impact of obesity on cognitive function has engendered considerable interest. Weight-adjusted waist index (WWI) emerged as a novel and innovative marker of obesity that has responded to weight-independent abdominal obesity. However, the association between WWI and cognitive function remains unclear.