Comparison of smoking behaviors and associated factors between HIV-infected and uninfected men in Guilin, China: a case-control study.

Background: Smoking is highly prevalent among HIV-infected individuals and is associated with high morbidity and mortality. Studies on smoking among HIV-infected individuals in China, especially compared to uninfected individuals, are scarce.

Purpose: This study aimed to investigate and compare the prevalence and factors associated with smoking between HIV-infected and uninfected men in Guilin, China.

Advancing the clinical assessment of glomerular podocyte pathology in kidney biopsies via super-resolution microscopy and angiopoietin-like 4 staining.

The tertiary structure of normal podocytes prevents protein from leaking into the urine. However, observing the complexity of podocytes is challenging because of the scale differences in their three-dimensional structure and the close proximity between neighboring cells in space. In this study, we explored podocyte-secreted angiopoietin-like 4 (ANGPTL4) as a potential morphological marker via super-resolution microscopy (SRM).

Spatial correlation of desorption events accelerates water exchange dynamics at Pt/water interfaces.

The altered solvation structures and dynamical properties of water molecules at the metal/water interfaces will affect the elementary step of an electrochemical process. Simulating the interfacial structure and dynamics with a realistic representation will provide us with a solid foundation to make a connection with experimental studies. To surmount the accuracy-efficiency tradeoff and provide dynamical insights, we use state-of-the-art machine learning molecular dynamics (MLMD) to study the water exchange dynamics, which are fundamental to adsorption/desorption and electrochemical reaction steps.

Visualization of Hg Stress on Plant Health at the Subcellular Level Revealed by a Highly Sensitive Fluorescent Sensor.

The presence of Hg causes substantial stress to plants, adversely affecting growth and health by disrupting cell cycle divisions, photosynthesis, and ionic homeostasis. Accurate visualization of the spatiotemporal distribution of Hg in plant tissues is crucial for the management of Hg pollution; however, the related research is still at its early stage. Herein, a small-molecule amphiphilic fluorescent probe (termed ) was developed for the specific detection of Hg with a high sensitivity (~16 nM).

Large language models facilitating modern molecular biology and novel drug development.

The latest breakthroughs in information technology and biotechnology have catalyzed a revolutionary shift within the modern healthcare landscape, with notable impacts from artificial intelligence (AI) and deep learning (DL). Particularly noteworthy is the adept application of large language models (LLMs), which enable seamless and efficient communication between scientific researchers and AI systems. These models capitalize on neural network (NN) architectures that demonstrate proficiency in natural language processing, thereby enhancing interactions.