Same-Slide Spatial Multi-Omics Integration Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment.

The advent of spatial transcriptomics and spatial proteomics have enabled profound insights into tissue organization to provide systems-level understanding of diseases. Both technologies currently remain largely independent, and emerging same slide spatial multi-omics approaches are generally limited in plex, spatial resolution, and analytical approaches. We introduce IN-situ DEtailed Phenotyping To High-resolution transcriptomics (IN-DEPTH), a streamlined and resource-effective approach compatible with various spatial platforms.

A study on the professional identity intervention of Chinese new nurses by Balint groups from the perspective of ABC theory of emotion-hong.

Objective: To explore the intervention effect of ABC theory on the professional identity and irrational beliefs of new Chinese nurses in Balint groups (BGs).

Methods: A total of 110 Chinese nurses newly recruited in August 2021 by a grade-A tertiary general hospital in Wenzhou, Zhejiang province were adopted as research objects. They were randomly divided into an experimental group and a control group, the experimental group spread out in groups to practice the BGs, and the control group did not have any intervention.

The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years.

Background: There has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia.

Objective: The aim of this study was to investigate the relationship between thigh circumference and sarcopenia, and explore the potential role of thigh circumference for sarcopenia screening among community-dwelling older adults.

Protein Phosphatase 2A Promotes CD8 T Cell Effector Function through the Augmentation of CD28 Costimulation.

Protein phosphatase 2A (PP2A) is one of the most abundant serine/threonine phosphatases and plays critical roles in regulating cell fate and function. We previously showed that PP2A regulates the differentiation of CD4 T cells and the development of thymocytes. Nevertheless, its role in CD8 T cells remains elusive.

Efficacy and safety of dual-targeted therapy for inflammatory bowel disease: a retrospective multicenter study in China.

Background: Treatment options for patients with refractory inflammatory bowel disease (IBD) or concomitant IBD and extraintestinal manifestations (EIM) are often limited.

Objective: This study aimed to examine the efficacy and safety of combining biologics or small molecules in patients with refractory IBD, active EIM, or active immune-mediated inflammatory disease (IMID).

Design: This was a retrospective and multicenter study.