Study on the effects of Massa Medicata Fermentata with different formulations on the intestinal microbiota and enzyme activities in mice with spleen deficiency constipation.

Objective: This study aims to explore the therapeutic mechanism of Massa Medicata Fermentata (MMF) with different formulations on spleen deficiency constipation in mice by analyzing gastrointestinal hormones, D-xylose, intestinal microbiota, and intestinal enzyme activities.

Methods: A spleen deficiency constipation model was established using an oral administration of Sennae Folium decoction combined with controlled diet and water intake. After successful model establishment, the mice with spleen deficiency constipation were treated with MMF S1, S2, S3.

The Role of the Toll-Like Receptor Signaling Pathway in Autoimmune Diseases and Treatment with Traditional Chinese Medicine: A Literature Review.

Toll-Like Receptors (TLRs) is a pattern recognition receptor that connects innate and adaptive immunity and participates in inflammatory responses play a key role in common autoimmune diseases such as Rheumatoid Arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, and Sjögren's syndrome (SS) by participating in antigen recognition, immune cell activation, and inflammatory factor release. Due to the multi-component and multi-target characteristics of traditional Chinese medicine (TCM), the role of TCM active ingredients acting on TLRs has been widely studied. This article describes the relationship between TLR and four autoimmune diseases, as well as a review of the efficacy of TLR intervention by active ingredients of traditional Chinese medicine.

[Disease burden and clinical status of congenital heart disease combined with heart failure in China: a survey and analysis].

To investigate the disease burden, clinical characteristics and independent risk factors affecting in-hospital outcomes of children with congenital heart disease (CHD) combined with heart failure (HF) in China. (1) Descriptive study: based on the global burden of disease study 2021, available data on children under 15 years of age with CHD and HF in China from 1990 to 2021 were collected. The prevalence and trends in different age subgroups (<1 year, 1-<2 years, 2-<5 years, 5-<10 years, 10-<15 years) were analyzed, and the annual percentage change (EAPC) was estimated using linear regression.

Evaluation of ecological geological environment carrying capacity and analysis of driving mechanisms based on normal cloud model and geodetector model.

The Luoyang area of the Yellow River Basin, as a typical resource-based city, its special industrial structure and complex geological structure make the ecological and geological environment of the area extremely fragile. In order to realize the sustainable development of the region in this fragile ecological-geological environment, it is necessary to study its Ecological Geological Environmental Carrying Capacity (EGECC) to better serve the regional ecological-geological environment restoration and management work. This study constructs an indicator system encompassing three subsystems: Geological Environment (GE), Social Environment (SE), and Ecological Environment (EE).

A non-associated constitutive model based on yld2004-18p yield criterion and its applications on sheet metal forming analysis.

For sheet metals, anisotropy is a significant property affecting sheet metal forming processes. The anisotropy of sheet metals is caused by the rolling process, and several anisotropic constitutive models have been proposed under the non-associated flow rule to describe the deformation and stress anisotropies of sheet metals independently. However, most of them are based on yield functions that are only identified by the experimental data of orthogonal axes, or yield functions that are applicable to only the plane stress state.