Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma.

Enhancer RNA (eRNA) has emerged as a key player in cancer biology, influencing various aspects of tumor development and progression. In this study, we investigated the role of eRNAs in kidney renal clear cell carcinoma (KIRC), the most common subtype of renal cell carcinoma. Leveraging high-throughput sequencing data and bioinformatics analysis, we identified differentially expressed eRNAs in KIRC and constructed eRNA-centric regulatory networks.

Methane Adsorption in Heterogeneous Potential Wells of Coal: Characterization Model and Applications.

In terms of the phenomenon of nonuniformity adsorption energy between methane and a natural heterogeneous coal surface, a heterogeneous potential well model is established in this study based on adsorption science and molecular dynamics theories. This model describes the methane adsorption positions in coal pores as a three-dimensional space composed of adsorption equipotential surfaces with varying depths of potential well, which emphasizes the heterogeneous distribution of methane adsorption potential well depths in coal and accurately describes the spatial distribution and energy states of methane molecules during methane adsorption and desorption in naturally heterogeneous coal. By taking the residual sum of squares (RSS) and Pearson correlation coefficient as indicators, the fitting accuracies of the Langmuir model and the heterogeneous potential well model for isothermal adsorption and desorption curves are compared so that the superiority of the heterogeneous potential well model in describing the adsorption and desorption of methane in natural coal is confirmed.

Factors That Influence Young Adults' Preferences for Virtual Reality Exergames in a Weight Control Setting: Qualitative Study.

Background: Obesity could compromise people's health and elevate the risk of numerous severe chronic conditions and premature mortality. Young adults are at high risk of adopting unhealthy lifestyles related to overweight and obesity, as they are at a phase marked by several significant life milestones that have been linked to weight gain. They gain weight rapidly and excess adiposity mostly accrues, compared with middle-aged and older adults when weight stabilizes or even decreases.

Ultrasonic combined pH shifting strategy for improving the stability of emulsion stabilized by yeast proteins: Focused on solubility, protein structure, interface properties.

In this study, the improvement mechanism of yeast proteins (YPs) with the ultrasonic and pH shifting treatment on the emulsion stability was investigated through the solubility, protein structure and interface behavior of YPs. Compared with only pH shifting or ultrasound treatment, the solubility of YPs with the combined treatment of ultrasonic and pH shifting was increased significantly. The soluble protein content of pH-U400 reached 85.