Low-flow ECCOR conjoined with renal replacement therapy platform to manage pulmonary vascular dysfunction with refractory hypercapnia in ARDS.

Background: Hypercapnia worsens lung vascular dysfunction during acute respiratory distress syndrome (ARDS). We tested whether an extracorporeal carbon dioxide removal (ECCOR) device based on a renal replacement therapy platform (Prismalung®) may reduce PaCO and alleviate lung vascular dysfunction in ARDS patients with refractory hypercapnia.

Methods: We planned to prospectively include 20 patients with moderate-to-severe ARDS, pulmonary vascular dysfunction on echocardiography, and PaCO ≥ 48 mmHg despite instrumental dead space reduction and the increase in respiratory rate.

Critically ill severe hypothyroidism: a retrospective multicenter cohort study.

Background: Severe hypothyroidism (SH) is a rare but life-threatening endocrine emergency. Only a few data are available on its management and outcomes of the most severe forms requiring ICU admission. We aimed to describe the clinical manifestations, management, and in-ICU and 6-month survival rates of these patients.

Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness.

Objective: Incidence of right ventricular (RV) failure in septic shock patients is not well known, and tricuspid annular plane systolic excursion (TAPSE) could be of limited value. We report the incidence of RV failure in patients with septic shock, its potential impact on the response to fluids, as well as TAPSE values.

Design: Ancillary study of the HEMOPRED prospective multicenter study includes patients under mechanical ventilation with circulatory failure.

Risk factors for surgical site infection after pancreatic surgery: a better postoperative antibiotic strategy is possible.

Introduction: Pancreatic surgery is associated with high morbidity, mainly due to infectious complications, so many centres use postoperative antibiotics (ATBpo) for all patients. However, antibiotic regimens vary according to local practices. The aims of this study were to describe the occurrence of surgical site infection (SSI) and ATBpo prescription after pancreatic surgery, and to determine the risk factors of postoperative SSI, in order to better define the clinical indications for ATBpo in this context.