Expanded non-invasive prenatal testing offers better detection of fetal copy number variations but not chromosomal aneuploidies.

Purpose: To evaluate the clinical performance of expanded non-invasive prenatal testing (NIPT-plus) and compare its effectiveness in screening for chromosomal aneuploidies with that of NIPT.

Methods: Screening results, confirmatory invasive testing results, and follow-up data from pregnant women who underwent either NIPT (6792 cases) or NIPT-Plus (5237 cases) testing at Luohe Central Hospital, China, from January 2019 to June 2023 were collected. The positive predictive value (PPV), sensitivity, specificity, and other indicators for different types of chromosomal abnormalities in NIPT/NIPT-plus screening were calculated.

MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis.

: The integration of microbiome and metabolome data could unveil profound insights into biological processes. However, widely used multi-omic data analyses often employ a stepwise mining approach, failing to harness the full potential of multi-omic datasets and leading to reduced detection accuracy. Synergistic analysis incorporating microbiome/metabolome data are essential for deeper understanding.

Interkingdom signaling between gastrointestinal hormones and the gut microbiome.

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones through mechanisms such as modulating the intestinal environment, producing metabolites, impacting mucosal barriers, generating immune and inflammatory responses, and releasing neurotransmitters. Conversely, gastrointestinal hormones exert feedback regulation on the gut microbiota by modulating the intestinal environment, nutrient absorption and utilization, and the bacterial biological behavior and composition.

Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.

Background: Many studies reported the influence of infants' gut microbiota on atopic dermatitis (AD) postnatally, yet the role of maternal gut microbiota and plasma metabolites in infants' AD remains largely unexplored.

Methods: Sixty-three pregnant mother-infants were enrolled and followed after childbirth in Guangzhou, China. Demographic information, maternal stool and plasma samples, and records for infants' AD were collected.

Analysis of the effect of three different blanching processes on the flavor profile of peeled and unpeeled broad beans.

Broad beans, a seasonal leguminous vegetable renowned for their distinctive flavor and high-quality plant protein, present unique opportunities for culinary and nutritional applications. To better understand the impact of various blanching processes on their characteristics, we employed headspace gas chromatography-ion mobility mass spectrometry (HS-GC-IMS) and biochemical tests to evaluate changes in color, volatile compound content, and levels of antioxidant-related substances following different blanching treatments. Our findings revealed that microwave blanching significantly influenced the a* metric and antioxidant capacity of broad beans.