Predicting transcriptional changes induced by molecules with MiTCP.

Studying the changes in cellular transcriptional profiles induced by small molecules can significantly advance our understanding of cellular state alterations and response mechanisms under chemical perturbations, which plays a crucial role in drug discovery and screening processes. Considering that experimental measurements need substantial time and cost, we developed a deep learning-based method called Molecule-induced Transcriptional Change Predictor (MiTCP) to predict changes in transcriptional profiles (CTPs) of 978 landmark genes induced by molecules. MiTCP utilizes graph neural network-based approaches to simultaneously model molecular structure representation and gene co-expression relationships, and integrates them for CTP prediction.

Preoperative CT-based radiomics nomogram to predict the micropapillary pattern in lung adenocarcinoma of size 2 cm or less.

Purpose: To develop and validate a radiomics nomogram model for predicting the micropapillary pattern (MPP) in lung adenocarcinoma (LUAD) tumors of ≤2 cm in size.

Methods: In this study, 300 LUAD patients from our institution were randomly divided into the training cohort (n = 210) and an internal validation cohort (n = 90) at a ratio of 7:3, besides, we selected 65 patients from another hospital as the external validation cohort. The region of interest of the tumor was delineated on the computed tomography (CT) images, and radiomics features were extracted.

Tebuconazole residue in wheat and food risks: Comparison among nano and conventional formulations.

Nanopesticides exhibit different residue patterns in crops after application compared to conventional formulations, thus affecting human dietary exposure. Residue, dissipation, and dietary exposure to tebuconazole nanoformulations (nanoemulsion and nano-capsules) and conventional formulations (suspension concentrate and micro-capsules) on wheat were investigated and compared. Nano-capsules (1950 μg/kg) and micro-capsules (1771 μg/kg) had significantly lower initial deposition on wheat-leaf than suspension concentrate (2666 μg/kg).

Narcolepsy in early childhood: a case report and a Mini review.

Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.

Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.

Background: Antibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early infants could provide information for therapeutic decision-making in the NICU.

Objectives: To explore the effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.