Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint.

Introduction: Tumor heterogeneity significantly complicates the selection of effective cancer treatments, as patient responses to drugs can vary widely. Personalized cancer therapy has emerged as a promising strategy to enhance treatment effectiveness and precision. This study aimed to develop a personalized drug recommendation model leveraging genomic profiles to optimize therapeutic outcomes.

Pim3 up-regulation by YY1 contributes to diabetes-induced cardiac hypertrophy and heart failure.

Objectives: The close relationship of proto-oncogenes to myocardial hypertrophy has long been recognized, and cardiac hypertrophy leads to heart failure (HF). However, whether proviral insertion of Moloney virus 3 kinase (Pim3), a proto-oncogene, contributes to cardiac hypertrophy in diabetes mellitus (DM) remains unknown. This study aims to investigate whether Pim3 is involved in DM-induced cardiac hypertrophy and HF and to elucidate its underlying mechanisms.

Copper-Catalyzed Annulation of α,β-Unsaturated Ketoximes with Dialkyl Acetylenedicarboxylates for the Synthesis of Highly Substituted Pyridines.

A copper-catalyzed [4 + 2] annulation protocol from readily available α,β-unsaturated ketoximes and dialkyl acetylenedicarboxylates has been achieved. The approach enables the expedient construction of a series of structurally new highly substituted pyridines with good functional group tolerance.

Enhancing doctor-patient communication using large language models for pathology report interpretation.

Background: Large language models (LLMs) are increasingly utilized in healthcare settings. Postoperative pathology reports, which are essential for diagnosing and determining treatment strategies for surgical patients, frequently include complex data that can be challenging for patients to comprehend. This complexity can adversely affect the quality of communication between doctors and patients about their diagnosis and treatment options, potentially impacting patient outcomes such as understanding of their condition, treatment adherence, and overall satisfaction.

Receptor binding, structure, and tissue tropism of cattle-infecting H5N1 avian influenza virus hemagglutinin.

The ongoing circulation of highly pathogenic avian influenza (HPAI) A (H5N1) viruses, particularly clade 2.3.4.