The role and research progress of tumor-associated macrophages in cervical cancer.

Tumor-associated macrophages (TAMs) are important immune cells in the tumor micro-environment (TME) and play a key role in the occurrence and development of cervical cancer. Besides, targeting TAMs can significantly inhibit cervical cancer tumor growth, invasion, metastasis, and angiogenesis as well as affect immune regulation. This review summarizes the correlation between TAM and tumors, the mechanism of action of TAM in cervical cancer, and the potential application of TAM in the treatment of cervical cancer.

Systolic Blood Pressure Time in Target Range and Cardiovascular Disease and Premature Death.

Background: Previous research has suggested that time-in-target range (TTR) for systolic blood pressure (SBP) was associated with adverse cardiovascular events, but real-world data studies remain limited.

Objectives: The purpose of this study was to estimate the SBP-TTR associated with cardiovascular disease (CVD) and premature death among the employed individuals with hypertension.

Methods: This study included 9,552 participants from the workplace hypertension management program initiated by the Kailuan Study in 2009.

Data-driven parametrization of molecular mechanics force fields for expansive chemical space coverage.

A force field is a critical component in molecular dynamics simulations for computational drug discovery. It must achieve high accuracy within the constraints of molecular mechanics' (MM) limited functional forms, which offers high computational efficiency. With the rapid expansion of synthetically accessible chemical space, traditional look-up table approaches face significant challenges.

Design and synthesis of coumarin-based amphoteric antimicrobials with biofilm interference and immunoregulation effects.

Bacterial infections pose a threat to human and animal health, and the formation of biofilm exacerbates the microbial threat. New antimicrobial agents to address this challenge are much needed. In this study, several new amphoteric compounds derived from the natural product coumarin were designed and synthesized by mimicking the structure and function of antimicrobial peptides.

Effects of non-pharmacological interventions on depressive and anxiety symptoms in pregnant women: a systematic review and network meta-analysis.

Background: Given the distinctive physiological characteristics of pregnant women, non-pharmacological therapies are increasingly being used to improve depressive and anxiety symptoms. Our objective was to explore and compare the impact of various non-pharmacological interventions in improving depressive and anxiety symptoms, and to identify the most effective strategies for pregnant women with depressive and/or anxiety symptoms.

Methods: We conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials (RCTs) that compared non-pharmacological interventions to usual care, from the inception of each database up to October 5, 2024.