Tryptanthrin alleviate lung fibrosis via suppression of MAPK/NF-κB and TGF-β1/SMAD signaling pathways in vitro and in vivo.

Idiopathic pulmonary fibrosis (IPF), a progressive interstitial lung disease of unknown etiology, remains a therapeutic challenge with limited treatment options. This study investigates the therapeutic potential and molecular mechanisms of Tryptanthrin, a bioactive indole quinazoline alkaloid derived from Isatis tinctoria L., in pulmonary fibrosis.

Self-assembled metal-coordinated nanoparticles for synergistic energy metabolism inhibition and low-temperature photothermal therapy.

Photothermal therapy has been observed to upregulate the heat shock protein 70 (HSP 70) expression in tumor cells, consequently diminishing the anti-tumor efficacy of the treatment. The expression of HSP 70 is intricately linked to the adenosine triphosphate (ATP) levels within tumors, suggesting that modulating energy metabolism could potentially enhance the effectiveness of photothermal therapy. To address these challenges, ATO-QUE-Fe-PVP K30 nanoparticles (AQFP NPs) were synthesized through the coordinated self-assembly of the oxidative phosphorylation (OXPHOS) inhibitor atovaquone (ATO) and the glycolysis inhibitor quercetin (QUE) with ferrous ions (Fe) for synergetic energy depletion and low-temperature photothermal therapy (LTPTT).

APOA1 promotes tumor proliferation and migration and may be a potential pan-cancer biomarker and immunotherapy target.

Introduction: Aberrant expression of APOA1 has been reported in various cancers. However, a comprehensive investigation into its role in cancer is currently lacking.

Methods: Online websites and databases such as TIMER2.

Short communication: Evaluating laying curve models and estimating genetic parameters for egg production traits in chickens.

The Qingyuan partridge chicken, a highly valued indigenous breed in China, requires optimised egg production traits to maximise economic returns. This study analysed weekly egg production data from 6 776 Qingyuan partridge chickens to compare the Grossman and Wood models in fitting individual egg-laying curves and identify the most robust model for estimating egg production persistency. Genetic parameters were estimated for three key traits: age at first egg (AFE), cumulative egg number up to 28 weeks (EN), and persistency derived from the Wood model, alongside weekly egg numbers using a random regression model.

Characterization of quorum quenching enzyme AiiA and its potential role in strawberry preservation.

Microbial spoilage in nutrient-rich strawberries has led to significant food waste and economic loss in the food industry. The quorum-quenching enzyme AiiA is believed to disrupt communication between cells by inactivating AHLs-based quorum sensing signals. Chitosan, a biopolymer derived from chitin, is widely used as a coating film to inhibit bacterial growth and prolong food shelf life.