Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders.

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of iWAT, offering potential therapeutic strategies for metabolic syndromes.

Efficiency and safety of automated label cleaning on multimodal retinal images.

Label noise is a common and important issue that would affect the model's performance in artificial intelligence. This study assessed the effectiveness and potential risks of automated label cleaning using an open-source framework, Cleanlab, in multi-category datasets of fundus photography and optical coherence tomography, with intentionally introduced label noise ranging from 0 to 70%. After six cycles of automatic cleaning, significant improvements are achieved in label accuracies (3.

Neural correlates of reciprocity bias: social debts modulate unfairness perception of violation during third-party observation.

The phenomenon of beneficiaries ignoring benefactors' violations, ranging from everyday favors to bribes, is widespread yet lacks targeted theoretical and empirical attention. We propose a conceptual framework that includes "social debt" and "reciprocity bias," where "social debt" is defined as information about benefits bestowed by benefactors and "reciprocity bias" as the influence of social debt on beneficiaries' perceptions and decisions in situations involving the benefactor. To investigate this bias in moral perception and its cognitive-neural mechanisms, we manipulated three levels of social debt (none, less, more) by varying the amount of unasked benefits that benefactors bestowed upon participants.

Dual-System Collaborative Model of Prosocial Risky Behavior and Cognitive Computation: A Review.

Prosocial risky behavior (PRB) refers to actions taken at personal risk for the benefit of others or societal welfare, combining risk-taking with prosocial intent, and involving the integrated processing of individual risk and social preferences. Building upon the review and evaluation of the definitions of PRB, existing research tools, theoretical models, and neural mechanisms, this paper elucidates the synergistic interaction and mechanisms of the emotional drive and cognitive reasoning systems in PRB. It constructs a dual-system collaborative model for PRB.