Suhexiang pill for acute ischemic stroke in real-world practice setting (SUNRISE): protocol of a multicenter registry.

Background: Suhexiang (SHX) pill is widely used for treating acute ischemic stroke (AIS). Experimental and randomized controlled trials suggested that SHX pill was beneficial for patients with AIS. However, the effectiveness of SHX pill in real-world practice setting remains unclear.

Recruitment of copiotrophic and autotrophic bacteria by hyperaccumulators enhances nutrient cycling to reclaim degraded soils at abandoned rare earth elements mining sites.

Hyperaccumulators harbor potentials for remediating rare earth elements (REEs)-contaminated soils. However, how they thrive in low-nutrient abandoned REEs mining sites is poorly understood. Three ferns (REEs-hyperaccumulators Dicranopteris pedata and Blechnum orientale, and non-hyperaccumulator Pteris vittata) along with their rhizosphere soils were collected to answer this question by comparing differences in soil nutrient levels, soil and plant REEs concentrations, and bacterial diversity, composition, and functions.

Decreasing the aggregation of photosensitizers to facilitate energy transfer for improved photodynamic therapy.

The mode of energy transfer between photosensitizers and oxygen determines the yield of singlet oxygen (O), crucial for photodynamic therapy (PDT). However, the aggregation of photosensitizers promotes electron transfer while inhibiting pure energy transfer, resulting in the generation of the hypotoxic superoxide anion (O) and consumption of substantial oxygen. Herein, we achieve the reduction of the aggregation of photosensitizers to inhibit electron transfer through classical chemical crosslinking, thereby boosting the production of O.

The impact of adverse childhood experiences on postpartum post-traumatic stress disorder in women: A prospective cohort study in China.

Background: Women are more prone to experience adverse childhood experiences (ACEs), placing them at higher risk of postpartum mental health disorders. However, research on ACEs, particularly their association with postpartum Post-Traumatic Stress Disorder (PTSD) in non-Western contexts, is limited.

Objective: To utilize a cumulative risk approach and latent class analysis (LCA) to operationalize ACEs among postpartum women in China and examine their association with postpartum PTSD.

HGF/c-Met Promotes Breast Cancer Tamoxifen Resistance Through the EZH2/HOTAIR-miR-141/200a Feedback Signaling Pathway.

Tamoxifen is one of the most frequently used endocrine medications for the treatment of estrogen receptor-positive (ER + ) breast cancer (BC). Unfortunately, tamoxifen resistance (TR) brings more challenges to the clinical treatment, and the mechanisms of TR have not yet been fully clarified. HGF/c-Met is closely associated with cancer metastasis, but whether it is involved in TR remains unclear.