Effects of partial replacement of soybean meal with and lysozyme on diarrheal incidence, plasma biochemical parameters, and immunity of weaned piglets.

Introduction: The study aimed to investigate the effects of and lysozyme on growth performance, diarrhea rate, immune function, plasma biochemical parameters, and gut microbiota and metabolites of weaned piglets.

Methods: Thirty weaned Xiangcun black piglets (BW, 11.47 ± 1.

Noninvasive prenatal diagnosis (NIPD) of non-syndromic hearing loss (NSHL) for singleton and twin pregnancies in the first trimester.

Background: Noninvasive prenatal diagnosis (NIPD) has been proven feasible for non-syndromic hearing loss (NSHL) in singleton pregnancies. However, previous research is limited to the second trimester and the application in twin pregnancies is blank. Here we provide a novel algorithmic approach to assess singleton and twin pregnancies in the first trimester.

Deep learning-based algorithm for classifying high-resolution computed tomography features in coal workers' pneumoconiosis.

Background: Coal workers' pneumoconiosis is a chronic occupational lung disease with considerable pulmonary complications, including irreversible lung diseases that are too complex to accurately identify via chest X-rays. The classification of clinical imaging features from high-resolution computed tomography might become a powerful clinical tool for diagnosing pneumoconiosis in the future.

Methods: All chest high-resolution computed tomography (HRCT) medical images presented in this work were obtained from 217 coal workers' pneumoconiosis (CWP) patients and dust-exposed workers.

Enhanced Nasal-to-Brain Drug Delivery by Multivalent Bioadhesive Nanoparticle Clusters for Cerebral Ischemic Reperfusion Injury Protection.

Following cerebral ischemia, reperfusion injury can worsen ischemia-induced functional, metabolic disturbances, and pathological damage upon blood flow restoration, potentially leading to irreversible harm. Yet, there's a dearth of advanced, localized drug delivery systems ensuring active pharmaceutical ingredient (API) efficacy in cerebral protection during ischemia-reperfusion. This study introduces a multivalent bioadhesive nanoparticle-cluster, merging bioadhesive nanoparticles (BNPs) with dendritic polyamidoamine (PAMAM), enhancing nose-to-brain delivery and brain protection efficacy against cerebral ischemia-reperfusion injuries (CIRI).

Designing rare earth borates as UV nonlinear optical crystals exhibiting strong second-harmonic generation responses.

Two new rare earth borate NLO crystals, KNaSrYBO and RbBaLuBO, were successfully designed and synthesized, which feature NLO-active [BO] groups and [Y/LuO] polyhedra. They exhibit notably short UV absorption cutoff edges below 200 nm, wide band gaps exceeding 6.2 eV, and strong second-harmonic generation intensities that are comparable to KDP.