Publications by authors named "X Nuvials"
There is no experience with ciprofloxacin for the treatment of carbapenemase-producing Gram-negative bacteria (CP-GNB) infections. This is a retrospective single-centre study where we describe the clinical evolution of all consecutive adult patients who received ciprofloxacin monotherapy for the treatment of CP-GNB infections. Primary outcomes were clinical failure (defined as death, lack of clinical improvement or a switch to another drug) at day 14 and 30-day all-cause mortality.
View Article and Find Full Text PDFIntroduction: Obesity constitutes a global public health problem, and knowledge about drug dosing in obese patients is limited. Clinical trials in critically ill patients rarely include obese individuals, resulting in a lack of specific dosing information in product data sheets. The aim of this literature review is to provide clinicians with efficient and safe guidelines for this group of patients.
View Article and Find Full Text PDFIntroduction: The prevalence of obesity represents a significant global public health challenge, and the available evidence concerning the appropriate dosing of pharmaceutical in patients with obesity is limited. It is uncommon for clinical trials in critically ill patients to include obese individuals, which results in a lack of specific dosing information in product data sheets. The objective of this literature review is to provide clinicians with efficacious and secure guidelines for this cohort of patients.
View Article and Find Full Text PDFBasal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: a systematic review and meta-analysis.
Diagn Progn Res
August 2023
Article Synopsis
- - The study investigates the effectiveness of four biomarkers (procalcitonin, C-reactive protein, interleukin-6, and presepsin) in predicting mortality in critically ill adults with sepsis, addressing inconsistencies found in previous research.
- - A systematic review and meta-analysis of 60 studies involving over 15,000 patients revealed a high risk of bias in more than 60% of assessments for these biomarkers as prognostic indicators.
- - The findings indicate that baseline measurements of these biomarkers do not reliably predict mortality outcomes, suggesting that their role in sepsis prognosis may be limited.
Objectives: Norfloxacin is indicated as primary or secondary prophylaxis for spontaneous bacterial peritonitis in patients with cirrhosis. A history of spontaneous bacterial peritonitis favors colonization by multidrug-resistant bacteria. Infections caused by these bacteria increase morbidity and mortality after transplant.
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