Unmet social needs and diverticulitis: a phenotyping algorithm and cross-sectional analysis.

Objective: To validate a phenotyping algorithm for gradations of diverticular disease severity and investigate relationships between unmet social needs and disease severity.

Materials And Methods: An algorithm was designed in the All of Us Research Program to identify diverticulosis, mild diverticulitis, and operative or recurrent diverticulitis requiring multiple inpatient admissions. This was validated in an independent institution and applied to a cohort in the All of Us Research Program.

Effects of essential amino acids availability on amino acids uptake, metabolism and casein synthesis in bovine mammary epithelial cells.

Under current dairy cow feeding conditions, the conversion efficiency of dietary nitrogen into milk protein is less than 30%. A thorough understanding of amino acid (AA) uptake and utilization in mammary in response to AA supply is essential for accurately modeling nutritional requirements. This study utilized bovine mammary epithelial cells (BMEC) as a model to investigate the effects of increasing total essential amino acid (EAA) concentrations (0.

A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance.

Biomolecular condensates, such as stress and germ granules, often contain subcompartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is composed of at least four ordered compartments, each housing distinct sets of proteins and RNAs. How these compartments form and why they are spatially ordered remains poorly understood.

Chiral europium halides with high-performance magnetic field tunable red circularly polarized luminescence at room temperature.

Chiral organic-inorganic hybrid metal halides as promising circularly polarized luminescence (CPL) emitter candidates hold great potential for high-definition displays and future spin-optoelectronics. The recent challenge lies primarily in developing high-performance red CPL emitters. Here, coupling the f-f transition characteristics of trivalent europium ions (Eu) with chirality, we construct the chiral Eu-based halides, (R/S-3BrMBA)EuCl, which exhibit strong and predictable red emission with large photoluminescence quantum yield (59.

Gender-specific network analysis of parenting styles, depressive symptoms, and anxiety symptoms among 5157 Chinese adolescents.

Background: In this study, we aimed to use network analyses to explore the gender-specific interactions between individual items of depressive symptoms, anxiety symptoms, and parenting styles in Chinese adolescents.

Methods: We conducted a cross-sectional study with a total of 5157 adolescents in 5 primary schools, 8 junior high schools, and 2 senior high schools in Shandong province, China. Male and female adolescents' networks were assessed in all grades using the Egna Minnen Betraffande Uppfostran (EMBU), the 9-item Patient Health Questionnaire (PHQ-9), and the 7-item Generalized Anxiety Disorder Assessment (GAD-7).