Effects and Safety of Botulinum Toxin Injection in Treatment of Androgenetic Alopecia: A Meta-analysis and Systematic Review.

Background: Androgenetic alopecia (AGA) is a prevalent condition that significantly affects the psychosocial well-being of many individuals, and its treatment remains a clinical challenge. Botulinum toxin (BTX) injections have been reported to have a therapeutic effect on AGA. Although several studies have explored the efficacy and safety of this novel treatment, most are clinical studies with small sample sizes.

Mfgnn: Multi-Scale Feature-Attentive Graph Neural Networks for Molecular Property Prediction.

In the realm of artificial intelligence-driven drug discovery (AIDD), accurately predicting the influence of molecular structures on their properties is a critical research focus. While deep learning models based on graph neural networks (GNNs) have made significant advancements in this area, prior studies have primarily concentrated on molecule-level representations, often neglecting the impact of functional group structures and the potential relationships between fragments on molecular property predictions. To address this gap, we introduce the multi-scale feature attention graph neural network (MfGNN), which enhances traditional atom-based molecular graph representations by incorporating fragment-level representations derived from chemically synthesizable BRICS fragments.

Heterointerface Built Up by Ultrathin Amorphous MoO Conformal Coating Enables VO·6HO with Superior Properties for Aqueous Zinc Batteries.

Layered VO·6HO is a promising candidate for aqueous zinc batteries (AZBs) but with moderate electrochemical performances. Herein, the charge storage properties of VO·6HO are markedly improved by building up the heterointerface on its surface using amorphous molybdenum trioxide as the heteromaterial. The amorphous molybdenum trioxide functioning as the proton reservoir enables the proton-involved electrochemical reactions and induces the formation of a built-in electric field along the [001] orientation at the heterointerface constructed by the (001) plane of VO·6HO, which could provide new diffusion pathways and extra sites for ion storage.

Modeling of auditory neuropathy spectrum disorders associated with the variant reveals impaired gap junction function of iPSC-derived glia-like support cells.

Auditory neuropathy spectrum disorder (ANSD) is an auditory dysfunction disorder characterized by impaired speech comprehension. Its etiology is complex and can be broadly categorized into genetic and non-genetic factors. mutation is identified as a causative factor in ANSD.

The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study.

Background: This study aimed to investigate the potential relationship between the newly defined adiposity metric, the Body Roundness Index (BRI), which assesses central obesity, and the development of new-onset hyperuricemia.

Methods: In the Kailuan cohort study from 2006 to 2019, 91,804 eligible participants were included. A multivariate Cox regression model was used to test the correlation between BRI and hyperuricemia.