Publications by authors named "X M Hart"
Objective: Therapeutic drug monitoring (TDM) is an important tool for treatment optimisation. Its usefulness has recently been demonstrated for some first-line antidepressants; however, few studies have been reported on the relationship between blood levels of mirtazapine and its antidepressant effects. The aim of this study was to investigate the association between blood concentration of mirtazapine and antidepressant response.
View Article and Find Full Text PDFBackground: For psychotic disorders (i.e. schizophrenia), pharmacotherapy plays a key role in controlling acute and long-term symptoms.
View Article and Find Full Text PDFArticle Synopsis
- Conventional antipsychotic drugs are ineffective for about one-third of schizophrenia patients, highlighting the need for non-dopaminergic treatment options.
- A systematic review of recent phase II and III clinical trials identified 16 promising compounds for schizophrenia treatment, including both monotherapies and add-on therapies.
- Several of these compounds showed efficacy for various symptoms of schizophrenia, suggesting new, targeted treatment strategies that differ from traditional antipsychotics.*
Introduction: The complex nature of neurocognitive impairment in schizophrenia has been discussed in light of the mixed effects of antipsychotic drugs, psychotic symptoms, dopamine D receptor blockade, and intelligence quotient (IQ). These factors have not been thoroughly examined before.
Methods: This study conducted a comprehensive re-analysis of the CATIE data using machine learning techniques, in particular Conditional Inference Tree (CTREE) analysis, to investigate associations between neurocognitive functions and moderating factors such as estimated trough dopamine D receptor blockade with risperidone, olanzapine, or ziprasidone, Positive and Negative Syndrome Scale (PANSS), and baseline IQ in 573 patients with schizophrenia.
Background: Compared with antipsychotics, the relationship between antidepressant blood (plasma or serum) concentrations and target engagement is less well-established.
Methods: We have discussed the literature on the relationship between plasma concentrations of antidepressant drugs and their target occupancy. Antidepressants reviewed in this work are citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, duloxetine, milnacipran, tricyclic antidepressants (amitriptyline, nortriptyline, and clomipramine), bupropion, tranylcypromine, moclobemide, and vortioxetine.