Combining solubilization and controlled release strategies to prepare pH-sensitive solid dispersion loaded with albendazole: and studies.

Albendazole (ABZ), classified as a class II basic drug under the Biopharmaceutics Classification System (BCS), is widely recognized for its therapeutic efficacy in treating and preventing trichuriasis. However, despite its clinical relevance, ABZ's oral administration presents challenges due to its poor solubility and pH sensitivity, which diminish its therapeutic effectiveness. Additionally, high dosing regimens of ABZ pose risks of developmental toxicity in animal models.

Image Findings from Dual-phase Computed Tomography Pulmonary Angiography for Diagnosing Tuberculosis-associated Fibrosing Mediastinitis.

Objective: Fibrosing mediastinitis (FM) is a rare and benign disease affecting the mediastinum and often causes pulmonary hypertension (PH). Timely diagnosis of PH caused by FM is clinically important to mitigate complications such as right heart failure in affected individuals. This retrospective study aimed to analyze the CT imaging characteristics of TB-related FM in patients with tuberculosis (TB).

Bafilomycin A1 mitigates subchondral bone degeneration and pain in TMJOA rats.

Background: Pain and disability are primary concerns for temporomandibular joint osteoarthritis (TMJOA) patients, and the efficacy of current treatments remains controversial. Overactive osteoclasts are associated with subchondral bone degeneration and pain in OA. The vacuolar H+-ATPase (V-ATPase) is crucial for differentiation and function in osteoclasts, but its role in TMJOA is not well defined.

Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex.

Successful navigation relies on reciprocal transformations between spatial representations in world-centered (allocentric) and self-centered (egocentric) frames of reference. The neural basis of allocentric spatial representations has been extensively investigated with grid, border, and head-direction cells in the medial entorhinal cortex (MEC) forming key components of a 'cognitive map'. Recently, egocentric spatial representations have also been identified in several brain regions, but evidence for the coexistence of neurons encoding spatial variables in each reference frame within MEC is so far lacking.

Finite element analysis of the plantar support for the medial longitudinal arch with flexible flatfoot.

Purpose: The present study is to explore the appropriate plantar support force for its effect on improving the collapse of the medial longitudinal arch with flexible flatfoot.

Methods: A finite element model with the plantar fascia attenuation was constructed simulating as flexible flatfoot. The appropriate plantar support force was evaluated.