Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation.

Lymphocyte activation gene 3 (LAG3) is a key receptor involved in the propagation of pathological proteins in Parkinson's disease (PD). This study investigates the role of neuronal LAG3 in mediating the binding, uptake, and propagation of α-synuclein (αSyn) preformed fibrils (PFFs). Using neuronal LAG3 conditional knockout mice and human induced pluripotent stem cells-derived dopaminergic (DA) neurons, we demonstrate that LAG3 expression is critical for pathogenic αSyn propagation.

Insights Into Metabolic Signatures and Regulatory Effect of Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status.

is a kind of popular functional food to be consumed by both healthy and diabetic people. As its major constituent, polysaccharide (DOP) is mainly utilized by gut microbiota. Despite distinctive gut microbiota composition between healthy and diabetic individuals, no study compared the interplay between DOP and gut microbiota under healthy and diabetic status.

Deciphering the endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association.

Small ubiquitin-like modifier (SUMO) plays a pivotal role in diverse cellular processes and is implicated in diseases such as cancer and neurodegenerative disorders. However, large-scale identification of endogenous SUMO-1 faces challenges due to limited enrichment methods and its lower abundance compared to SUMO-2/3. Here we propose a novel combinatorial peptide strategy, combined with anti-adhesive polymer development, to enrich endogenous SUMO-1 modified peptides, revealing a comprehensive SUMOylation landscape.

Designing a filler material to reduce dielectric loss in epoxy-based substrates for high-frequency applications.

In response to the demand for epoxy-based dielectric substrates with low dielectric loss in high-frequency and high-speed signal transmission applications, this study presents a surface-engineered filler material. Utilizing ball-milling, surface-modified aluminum flakes containing organic (stearic acid) and inorganic (aluminum oxide) coatings are developed. Incorporation of the filler into the epoxy matrix results in a significant increase in dielectric permittivity, by nearly 5 times (from 4.

Pregnancy Loss Was Associated With the Increased Risk of Cardiovascular Diseases in Middle-Aged Women: Evidence From the China Health and Retirement Longitudinal Study.

Objectives: Significant associations between pregnancy loss and risk of future maternal cardiovascular disease (CVD) have been found in Western countries, but the association in China is still unclear. Therefore, this study aimed to investigate the associations of pregnancy loss, number of pregnancy losses, subtype of pregnancy loss (i.e.