Survival analysis of recurrent ovarian cancer under different PARP inhibitor treatment patterns: a single-center retrospective study.

Objective: To compare the effects of different treatment modes containing PARPis and traditional treatment modes on the survival of patients with recurrent ovarian cancer.

Methods: From December 2012 to December 2023, 131 recurrent ovarian cancer patients were screened. The patients were followed up retrospectively, and the relevant data was collected and analyzed.

Cost-effective production of meaty aroma from porcine cells for hybrid cultivated meat.

Cultivated meats are typically hybrids of animal cells and plant proteins, but their high production costs limit their scalability. This study explores a cost-effective alternative by hypothesizing that controlling the Maillard and lipid thermal degradation reactions in pure cells can create a meaty aroma that could be extracted from minimal cell quantities. Using spontaneously immortalized porcine myoblasts and fibroblasts adapted to suspension culture with a 1 % serum concentration, we developed a method to isolate flavor precursors via freeze-thawing.

Research of mesoporous silica loaded lignin to enhance the anti-corrosion and anti-weathering performance of epoxy surface.

A new type of filler was added to epoxy resin to prepare a composite coating with excellent corrosion and weathering resistance. The simple synthesis process and nonpolluting raw materials of this filler contribute to the development of green chemistry. Specifically, lignin was encapsulated in mesoporous silica, the synergistic effect between the two resulted in the formation of lignin/mesoporous silica composite particles (MSN-L) with excellent ultraviolet (UV) resistance.

Protein Detection Based on Field-Effect Transistor Biosensors for Diagnosing Diseases.

Proteins have been one of the most important biomarkers for diagnosing diseases, and field-effect transistor (FET) biosensors possess high sensitivity; are label-free; and feature real-time detection, rapidity, and easy integration for protein detection. FET biosensors are mainly made up of FET parts, such as channel materials, and bio parts, such as receptors. This Tutorial provides an in-depth exploration of FET biosensors for protein detection from the composition perspective and discusses the commercialization of point-of-care diagnostics of proteins based on FET biosensors.

Thalamic functional connectivity on 7-Tesla magnetic resonance imaging and its relation to motor signs in early-stage Parkinson's disease.

Background: It is well known that dysfunction of thalamocortical circuity generates the motor signs that lead to distinct disease processes and prognoses in Parkinson's disease (PD). This study aimed to leverage ultrahigh-field magnetic resonance imaging (MRI) to identify the connectivity alterations of thalamocortical circuity and clarify their relation to motor signs in early PD.

Methods: Patients with early-stage PD (n=55) and healthy controls (HCs, n=56) were recruited from March 2022 to July 2023.